The role of postoperative external-beam radiotherapy in the management of patients with papillary thyroid cancer invading the trachea

Ki Chang Keum, Yang Gun Suh, Woong Sub Koom, Jaeho Cho, Su Jung Shim, Chang Geol Lee, Chung Soo Park, Woong Youn Chung, Gwi Eon Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Purpose: To determine the role of adjuvant external-beam radiotherapy (EBRT) in the management of patients with well-differentiated thyroid cancer invading the trachea. Methods and Materials: Of 1,098 thyroid cancer patients, 68 (6%) were found to have tracheal invasion, and they all received "shave" excision of the tracheal cartilage. Among them, 12 patients had no postoperative residuum, 43 patients had microscopic residuum, and 13 patients had macroscopic residuum. All patients were divided into two groups according to treatment modality with or without EBRT; (1) the control group (n = 43) and (2) the EBRT group (n = 25). Results: The locoregional recurrence rate for EBRT patients was much lower than that of control patients (51% for the control group vs. 8% for the EBRT group) (p < 0.01). The 10-year local progression-free survival rate for the EBRT group was significantly better than that of the control group (89% in the EBRT group vs. 38% in the control group) (log-rank, p < 0.01). The use of adjuvant EBRT after conservative surgery was an independent prognostic factor in univariate and multivariate analyses. Conclusions: External-beam radiotherapy was found to be effective, particularly in patients with thyroid cancer invading the trachea with microscopic or gross residuum after conservative surgery.

Original languageEnglish
Pages (from-to)474-480
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume65
Issue number2
DOIs
Publication statusPublished - 2006 Jun 1

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trachea
Trachea
radiation therapy
Radiotherapy
cancer
Thyroid Neoplasms
Control Groups
surgery
Papillary Thyroid cancer
cartilage
progressions
Disease-Free Survival
Cartilage
Multivariate Analysis
Survival Rate
Recurrence

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Keum, Ki Chang ; Suh, Yang Gun ; Koom, Woong Sub ; Cho, Jaeho ; Shim, Su Jung ; Lee, Chang Geol ; Park, Chung Soo ; Chung, Woong Youn ; Kim, Gwi Eon. / The role of postoperative external-beam radiotherapy in the management of patients with papillary thyroid cancer invading the trachea. In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 65, No. 2. pp. 474-480.
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The role of postoperative external-beam radiotherapy in the management of patients with papillary thyroid cancer invading the trachea. / Keum, Ki Chang; Suh, Yang Gun; Koom, Woong Sub; Cho, Jaeho; Shim, Su Jung; Lee, Chang Geol; Park, Chung Soo; Chung, Woong Youn; Kim, Gwi Eon.

In: International Journal of Radiation Oncology Biology Physics, Vol. 65, No. 2, 01.06.2006, p. 474-480.

Research output: Contribution to journalArticle

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N2 - Purpose: To determine the role of adjuvant external-beam radiotherapy (EBRT) in the management of patients with well-differentiated thyroid cancer invading the trachea. Methods and Materials: Of 1,098 thyroid cancer patients, 68 (6%) were found to have tracheal invasion, and they all received "shave" excision of the tracheal cartilage. Among them, 12 patients had no postoperative residuum, 43 patients had microscopic residuum, and 13 patients had macroscopic residuum. All patients were divided into two groups according to treatment modality with or without EBRT; (1) the control group (n = 43) and (2) the EBRT group (n = 25). Results: The locoregional recurrence rate for EBRT patients was much lower than that of control patients (51% for the control group vs. 8% for the EBRT group) (p < 0.01). The 10-year local progression-free survival rate for the EBRT group was significantly better than that of the control group (89% in the EBRT group vs. 38% in the control group) (log-rank, p < 0.01). The use of adjuvant EBRT after conservative surgery was an independent prognostic factor in univariate and multivariate analyses. Conclusions: External-beam radiotherapy was found to be effective, particularly in patients with thyroid cancer invading the trachea with microscopic or gross residuum after conservative surgery.

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