The role of radiation treatment in management of extrahepatic biliary tract metastasis from gastric carcinoma

Gwi E. Kim, Hyun S. Shin, Jin S. Seong, John J.K. Loh, Chang O. Suh, Jong T. Lee, Jae K. Roh, Byung S. Kim, Won H. Kim, Myung W. Kim, Jin S. Min

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Abstract

Purpose: To determine the proper role of radiation treatment in the management of patients with extrahepatic biliary tract metastasis due to recurrent gastric cancer. Methods and Materials: Twenty patients with malignant biliary obstruction due to recurrent gastric carcinoma after gastrectomy were treated with palliative intent at the Yonsei University College of Medicine from 1986 to 1990. Treatment consisted of external drainage alone in 11 patients (Group 1) and external drainage followed by radiation treatment in nine patients (Group II). Five of nine patients in Group 11 underwent external irradiation in combination with intraluminal brachytherapy using high dose rate Iridium-192 (Ir-192) sources within the expandable intrabiliary prosthesis, a Gianturco stent, inserted transhepatically at the site of obstruction. Results: An excellent local response was observed in five of nine patients in Group II, in whom biliary patency was restored following treatment so that the external drainage catheter could be removed. Prolongation of median survival was observed in Group II (9 months) as compared to Group I (2 months). There were no serious treatment-related complications with this approach. Conclusion: This treatment approach with external radiotherapy ± intraluminal brachytherapy could achieve effective palliation and improve the quality of life in selected patients with extrahepatic biliary metastasis from gastric carcinoma.

Original languageEnglish
Pages (from-to)711-717
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Volume28
Issue number3
DOIs
Publication statusPublished - 1994 Feb 1

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Biliary Tract
metastasis
Stomach
cancer
Radiation
Neoplasm Metastasis
Carcinoma
radiation
drainage
Drainage
Brachytherapy
Therapeutics
Iridium
prolongation
Gastrectomy
iridium
medicine
Prostheses and Implants
Stomach Neoplasms
Stents

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Kim, Gwi E. ; Shin, Hyun S. ; Seong, Jin S. ; Loh, John J.K. ; Suh, Chang O. ; Lee, Jong T. ; Roh, Jae K. ; Kim, Byung S. ; Kim, Won H. ; Kim, Myung W. ; Min, Jin S. / The role of radiation treatment in management of extrahepatic biliary tract metastasis from gastric carcinoma. In: International journal of radiation oncology, biology, physics. 1994 ; Vol. 28, No. 3. pp. 711-717.
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abstract = "Purpose: To determine the proper role of radiation treatment in the management of patients with extrahepatic biliary tract metastasis due to recurrent gastric cancer. Methods and Materials: Twenty patients with malignant biliary obstruction due to recurrent gastric carcinoma after gastrectomy were treated with palliative intent at the Yonsei University College of Medicine from 1986 to 1990. Treatment consisted of external drainage alone in 11 patients (Group 1) and external drainage followed by radiation treatment in nine patients (Group II). Five of nine patients in Group 11 underwent external irradiation in combination with intraluminal brachytherapy using high dose rate Iridium-192 (Ir-192) sources within the expandable intrabiliary prosthesis, a Gianturco stent, inserted transhepatically at the site of obstruction. Results: An excellent local response was observed in five of nine patients in Group II, in whom biliary patency was restored following treatment so that the external drainage catheter could be removed. Prolongation of median survival was observed in Group II (9 months) as compared to Group I (2 months). There were no serious treatment-related complications with this approach. Conclusion: This treatment approach with external radiotherapy ± intraluminal brachytherapy could achieve effective palliation and improve the quality of life in selected patients with extrahepatic biliary metastasis from gastric carcinoma.",
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The role of radiation treatment in management of extrahepatic biliary tract metastasis from gastric carcinoma. / Kim, Gwi E.; Shin, Hyun S.; Seong, Jin S.; Loh, John J.K.; Suh, Chang O.; Lee, Jong T.; Roh, Jae K.; Kim, Byung S.; Kim, Won H.; Kim, Myung W.; Min, Jin S.

In: International journal of radiation oncology, biology, physics, Vol. 28, No. 3, 01.02.1994, p. 711-717.

Research output: Contribution to journalArticle

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T1 - The role of radiation treatment in management of extrahepatic biliary tract metastasis from gastric carcinoma

AU - Kim, Gwi E.

AU - Shin, Hyun S.

AU - Seong, Jin S.

AU - Loh, John J.K.

AU - Suh, Chang O.

AU - Lee, Jong T.

AU - Roh, Jae K.

AU - Kim, Byung S.

AU - Kim, Won H.

AU - Kim, Myung W.

AU - Min, Jin S.

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N2 - Purpose: To determine the proper role of radiation treatment in the management of patients with extrahepatic biliary tract metastasis due to recurrent gastric cancer. Methods and Materials: Twenty patients with malignant biliary obstruction due to recurrent gastric carcinoma after gastrectomy were treated with palliative intent at the Yonsei University College of Medicine from 1986 to 1990. Treatment consisted of external drainage alone in 11 patients (Group 1) and external drainage followed by radiation treatment in nine patients (Group II). Five of nine patients in Group 11 underwent external irradiation in combination with intraluminal brachytherapy using high dose rate Iridium-192 (Ir-192) sources within the expandable intrabiliary prosthesis, a Gianturco stent, inserted transhepatically at the site of obstruction. Results: An excellent local response was observed in five of nine patients in Group II, in whom biliary patency was restored following treatment so that the external drainage catheter could be removed. Prolongation of median survival was observed in Group II (9 months) as compared to Group I (2 months). There were no serious treatment-related complications with this approach. Conclusion: This treatment approach with external radiotherapy ± intraluminal brachytherapy could achieve effective palliation and improve the quality of life in selected patients with extrahepatic biliary metastasis from gastric carcinoma.

AB - Purpose: To determine the proper role of radiation treatment in the management of patients with extrahepatic biliary tract metastasis due to recurrent gastric cancer. Methods and Materials: Twenty patients with malignant biliary obstruction due to recurrent gastric carcinoma after gastrectomy were treated with palliative intent at the Yonsei University College of Medicine from 1986 to 1990. Treatment consisted of external drainage alone in 11 patients (Group 1) and external drainage followed by radiation treatment in nine patients (Group II). Five of nine patients in Group 11 underwent external irradiation in combination with intraluminal brachytherapy using high dose rate Iridium-192 (Ir-192) sources within the expandable intrabiliary prosthesis, a Gianturco stent, inserted transhepatically at the site of obstruction. Results: An excellent local response was observed in five of nine patients in Group II, in whom biliary patency was restored following treatment so that the external drainage catheter could be removed. Prolongation of median survival was observed in Group II (9 months) as compared to Group I (2 months). There were no serious treatment-related complications with this approach. Conclusion: This treatment approach with external radiotherapy ± intraluminal brachytherapy could achieve effective palliation and improve the quality of life in selected patients with extrahepatic biliary metastasis from gastric carcinoma.

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