The role of S100A14 in epithelial ovarian tumors

Hanbyoul Cho, Ha Yeon Shin, Sunghoon Kim, Jane Seon Young Kim, Joon Yong Chung, Eun Joo Chung, Kyung Hee Chun, Stephen M. Hewitt, Jae-Hoon Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

S100A14 is an EF-hand calcium-binding protein that has been reported to be involved in the progression of many malignancies. However, its role in ovarian cancer has not yet been clarified. In this study, we investigated the significance of S100A14 expression in epithelial ovarian cancers (EOCs) as well as it's mechanism of action. On both RNA and protein levels, S100A14 was overexpressed in transformed cells. Immunohistochemical staining demonstrated that S100A14 expression was associated with advanced stage (P < 0.001) and poor tumor grade (P < 0.001). Moreover, S100A14 overexpression was an independent prognostic factor for overall survival (HR = 4.53, P = 0.029). We also investigated S100A14's functional role by employing lentiviral-mediated overexpression and knockdown in EOC cells. S100A14 overexpression promoted cell proliferation, tumorigenesis, migration, and invasion, whereas S100A14 knockdown inhibited these properties. TOV112D cells that overexpressed S100A14 also exhibited greater tumor growth potential in xenografted mice. S100A14 promoted such a malignant phenotype in EOC cells through the PI3K/Akt pathway. Taken together, our data indicate that S100A14 has a crucial role in EOC progression, and its overexpression is associated with poor prognosis. Further study of S100A14's molecular mechanisms may lead to the development of a novel therapeutic target for ovarian cancer.

Original languageEnglish
Pages (from-to)3482-3496
Number of pages15
JournalOncotarget
Volume5
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

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Ovarian Neoplasms
Neoplasms
EF Hand Motifs
Calcium-Binding Proteins
Phosphatidylinositol 3-Kinases
Carcinogenesis
Cell Proliferation
RNA
Staining and Labeling
Phenotype
Ovarian epithelial cancer
Growth
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Cho, H., Shin, H. Y., Kim, S., Kim, J. S. Y., Chung, J. Y., Chung, E. J., ... Kim, J-H. (2014). The role of S100A14 in epithelial ovarian tumors. Oncotarget, 5(11), 3482-3496. https://doi.org/10.18632/oncotarget.1947
Cho, Hanbyoul ; Shin, Ha Yeon ; Kim, Sunghoon ; Kim, Jane Seon Young ; Chung, Joon Yong ; Chung, Eun Joo ; Chun, Kyung Hee ; Hewitt, Stephen M. ; Kim, Jae-Hoon. / The role of S100A14 in epithelial ovarian tumors. In: Oncotarget. 2014 ; Vol. 5, No. 11. pp. 3482-3496.
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Cho, H, Shin, HY, Kim, S, Kim, JSY, Chung, JY, Chung, EJ, Chun, KH, Hewitt, SM & Kim, J-H 2014, 'The role of S100A14 in epithelial ovarian tumors', Oncotarget, vol. 5, no. 11, pp. 3482-3496. https://doi.org/10.18632/oncotarget.1947

The role of S100A14 in epithelial ovarian tumors. / Cho, Hanbyoul; Shin, Ha Yeon; Kim, Sunghoon; Kim, Jane Seon Young; Chung, Joon Yong; Chung, Eun Joo; Chun, Kyung Hee; Hewitt, Stephen M.; Kim, Jae-Hoon.

In: Oncotarget, Vol. 5, No. 11, 01.01.2014, p. 3482-3496.

Research output: Contribution to journalArticle

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Cho H, Shin HY, Kim S, Kim JSY, Chung JY, Chung EJ et al. The role of S100A14 in epithelial ovarian tumors. Oncotarget. 2014 Jan 1;5(11):3482-3496. https://doi.org/10.18632/oncotarget.1947