The role of 18F-fluorodeoxyglucose-positron emission tomography in the assessment of disease activity in patients with takayasu arteritis

Kwang Hoon Lee, Arthur Cho, Yun Jung Choi, Sang Won Lee, You Jung Ha, Se Jin Jung, Min Chan Park, Jong Doo Lee, Soo Kon Lee, Yong Beom Park

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective The assessment of disease activity in Takayasu arteritis (TA) is difficult in clinical situations because clinical symptoms and laboratory parameters do not always reflect the actual inflammation of the arterial wall. We undertook this study to comprehensively investigate the role of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in the assessment of disease activity in patients with TA. Methods We performed a retrospective chart review of 53 FDG-PET scans in 38 patients with TA. We measured 18F-fluorodeoxyglucose ( 18F-FDG) accumulation in the vascular wall of the large vessel using semiquantitative (visual grade) and quantitative (standard uptake value intensity) analyses. Clinical disease activity was evaluated based on the National Institutes of Health criteria for active TA, and erythrocyte sedimentation rates (ESRs) and C-reactive protein (CRP) levels were measured. Results At baseline, active vascular 18F-FDG uptake (visual grade ≥2) was observed in 18 of 24 patients with active disease and in 5 of 14 patients with inactive disease. There was a significant association between clinical disease activity and disease activity judged by FDG-PET (P = 0.008). Visual grade, standard uptake value intensity, and the number of vascular lesions with active 18F-FDG uptake were significantly higher in patients with active disease and correlated well with the ESR and CRP levels. In 15 followup FDG-PET scans, the changes in visual grade, areas of active vascular 18F-FDG uptake, and standard uptake value intensity reflected changes in clinical disease activity. Conclusion 18F-FDG uptake was associated with clinical disease activity and markers of inflammation, and FDG-PET reflected changes in clinical disease activity in patients with TA. FDG-PET may be a useful tool for aiding in the assessment of disease activity in patients with TA.

Original languageEnglish
Pages (from-to)866-875
Number of pages10
JournalArthritis and Rheumatism
Volume64
Issue number3
DOIs
Publication statusPublished - 2012 Mar

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'The role of <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography in the assessment of disease activity in patients with takayasu arteritis'. Together they form a unique fingerprint.

  • Cite this