The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus

Seong Hee Shim, Chan Yun Kim, Joon Mo Kim, Da Yeong Kim, Yang Jae Kim, Jeong Hun Bae, Ki Chul Sung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose. To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM). Design. Retrospective, cross-sectional study. Participants. DM subjects who underwent brachial-Ankle pulse wave velocity (baPWV) were recruited. Methods. Glaucoma patients (n=75) and age-matched control subjects (n=92) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n=55) and primary open-Angle glaucoma (POAG) based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group. Main Outcome Measures. BaPWV in glaucoma with DM patients. Results. Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03-13.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group. Conclusions. In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.

Original languageEnglish
Article number425835
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015 Jan 1

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Vascular Stiffness
Open Angle Glaucoma
Medical problems
Glaucoma
Diabetes Mellitus
Stiffness
Pulse Wave Analysis
Ankle
Regression analysis
Logistics
Arm
Logistic Models
Regression Analysis
Low Tension Glaucoma
Cross-Sectional Studies
Odds Ratio
Outcome Assessment (Health Care)
Control Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Shim, Seong Hee ; Kim, Chan Yun ; Kim, Joon Mo ; Kim, Da Yeong ; Kim, Yang Jae ; Bae, Jeong Hun ; Sung, Ki Chul. / The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus. In: BioMed Research International. 2015 ; Vol. 2015.
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abstract = "Purpose. To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM). Design. Retrospective, cross-sectional study. Participants. DM subjects who underwent brachial-Ankle pulse wave velocity (baPWV) were recruited. Methods. Glaucoma patients (n=75) and age-matched control subjects (n=92) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n=55) and primary open-Angle glaucoma (POAG) based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group. Main Outcome Measures. BaPWV in glaucoma with DM patients. Results. Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95{\%} CI: 1.03-13.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group. Conclusions. In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.",
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The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus. / Shim, Seong Hee; Kim, Chan Yun; Kim, Joon Mo; Kim, Da Yeong; Kim, Yang Jae; Bae, Jeong Hun; Sung, Ki Chul.

In: BioMed Research International, Vol. 2015, 425835, 01.01.2015.

Research output: Contribution to journalArticle

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AU - Bae, Jeong Hun

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N2 - Purpose. To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM). Design. Retrospective, cross-sectional study. Participants. DM subjects who underwent brachial-Ankle pulse wave velocity (baPWV) were recruited. Methods. Glaucoma patients (n=75) and age-matched control subjects (n=92) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n=55) and primary open-Angle glaucoma (POAG) based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group. Main Outcome Measures. BaPWV in glaucoma with DM patients. Results. Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03-13.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group. Conclusions. In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.

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