The roles of radiotherapy and chemotherapy in the era of multimodal treatment for early-stage nasal-type extranodal natural killer/T-cell lymphoma

Tae Hyung Kim, Jinseok Kim, Yang Gun Suh, Jaeho Cho, Woo Ick Yang, Chang-Ok Suh

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Abstract

Purpose: To evaluate radiotherapy (RT) and chemotherapy (CT) treatments of early-stage extranodal natural killer/T-cell lymphoma (ENKTL). Materials and Methods: Fifty-five patients with stage I or II ENKTL [n=39 (71%) and 16 (29%) patients, respectively] who were treated with RT between 1999 and 2013 were analyzed retrospectively. The median age was 54 years (range, 24–81). Patients were grouped by treatment modality as RT alone [n=19 (35%)], upfront CT plus RT [CT+RT, n=16 (29%)], and concurrent chemoradiotherapy [CCRT, n=20 (36%)]. The median RT dose was 48 Gy. Patient characteristics between each treatment group were well balanced. Patterns of failure and survival were analyzed. Results: The overall response rate after RT was 94.6%. Ten patients experienced distant failure, and seven experienced local failure comprising five in-field and two out-field failures. The local and distant failure rates in the RT-alone group were the same (16%). In the CT+RT group, the most common failure sites were local (19%). In the CCRT group, the most common failures were distant (25%). At a median follow-up of 56 months (range, 1–178 months), the 5-year overall survival (OS) and progression-free survival rates were 66% and 54%, respectively. The 5-year OS rate for the RT-alone and CT+RT groups were 76% and 69%, respectively, and the 2-year OS rate for the CCRT group was 62% (p=0.388). Conclusion: In the era of multimodal treatment for ENKTL, RT alone using advanced techniques should be considered for local disease control, whereas maintenance CT regimens should be considered for distant disease control.

Original languageEnglish
Pages (from-to)846-854
Number of pages9
JournalYonsei medical journal
Volume57
Issue number4
DOIs
Publication statusPublished - 2016 Jul 1

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Combined Modality Therapy
Natural Killer T-Cells
T-Cell Lymphoma
Nose
Radiotherapy
Drug Therapy
Survival Rate
Maintenance Chemotherapy
Survival
Chemoradiotherapy
Disease-Free Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{4cb3ded9e3be4997919af9b32984ed4f,
title = "The roles of radiotherapy and chemotherapy in the era of multimodal treatment for early-stage nasal-type extranodal natural killer/T-cell lymphoma",
abstract = "Purpose: To evaluate radiotherapy (RT) and chemotherapy (CT) treatments of early-stage extranodal natural killer/T-cell lymphoma (ENKTL). Materials and Methods: Fifty-five patients with stage I or II ENKTL [n=39 (71{\%}) and 16 (29{\%}) patients, respectively] who were treated with RT between 1999 and 2013 were analyzed retrospectively. The median age was 54 years (range, 24–81). Patients were grouped by treatment modality as RT alone [n=19 (35{\%})], upfront CT plus RT [CT+RT, n=16 (29{\%})], and concurrent chemoradiotherapy [CCRT, n=20 (36{\%})]. The median RT dose was 48 Gy. Patient characteristics between each treatment group were well balanced. Patterns of failure and survival were analyzed. Results: The overall response rate after RT was 94.6{\%}. Ten patients experienced distant failure, and seven experienced local failure comprising five in-field and two out-field failures. The local and distant failure rates in the RT-alone group were the same (16{\%}). In the CT+RT group, the most common failure sites were local (19{\%}). In the CCRT group, the most common failures were distant (25{\%}). At a median follow-up of 56 months (range, 1–178 months), the 5-year overall survival (OS) and progression-free survival rates were 66{\%} and 54{\%}, respectively. The 5-year OS rate for the RT-alone and CT+RT groups were 76{\%} and 69{\%}, respectively, and the 2-year OS rate for the CCRT group was 62{\%} (p=0.388). Conclusion: In the era of multimodal treatment for ENKTL, RT alone using advanced techniques should be considered for local disease control, whereas maintenance CT regimens should be considered for distant disease control.",
author = "Kim, {Tae Hyung} and Jinseok Kim and Suh, {Yang Gun} and Jaeho Cho and Yang, {Woo Ick} and Chang-Ok Suh",
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The roles of radiotherapy and chemotherapy in the era of multimodal treatment for early-stage nasal-type extranodal natural killer/T-cell lymphoma. / Kim, Tae Hyung; Kim, Jinseok; Suh, Yang Gun; Cho, Jaeho; Yang, Woo Ick; Suh, Chang-Ok.

In: Yonsei medical journal, Vol. 57, No. 4, 01.07.2016, p. 846-854.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The roles of radiotherapy and chemotherapy in the era of multimodal treatment for early-stage nasal-type extranodal natural killer/T-cell lymphoma

AU - Kim, Tae Hyung

AU - Kim, Jinseok

AU - Suh, Yang Gun

AU - Cho, Jaeho

AU - Yang, Woo Ick

AU - Suh, Chang-Ok

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Purpose: To evaluate radiotherapy (RT) and chemotherapy (CT) treatments of early-stage extranodal natural killer/T-cell lymphoma (ENKTL). Materials and Methods: Fifty-five patients with stage I or II ENKTL [n=39 (71%) and 16 (29%) patients, respectively] who were treated with RT between 1999 and 2013 were analyzed retrospectively. The median age was 54 years (range, 24–81). Patients were grouped by treatment modality as RT alone [n=19 (35%)], upfront CT plus RT [CT+RT, n=16 (29%)], and concurrent chemoradiotherapy [CCRT, n=20 (36%)]. The median RT dose was 48 Gy. Patient characteristics between each treatment group were well balanced. Patterns of failure and survival were analyzed. Results: The overall response rate after RT was 94.6%. Ten patients experienced distant failure, and seven experienced local failure comprising five in-field and two out-field failures. The local and distant failure rates in the RT-alone group were the same (16%). In the CT+RT group, the most common failure sites were local (19%). In the CCRT group, the most common failures were distant (25%). At a median follow-up of 56 months (range, 1–178 months), the 5-year overall survival (OS) and progression-free survival rates were 66% and 54%, respectively. The 5-year OS rate for the RT-alone and CT+RT groups were 76% and 69%, respectively, and the 2-year OS rate for the CCRT group was 62% (p=0.388). Conclusion: In the era of multimodal treatment for ENKTL, RT alone using advanced techniques should be considered for local disease control, whereas maintenance CT regimens should be considered for distant disease control.

AB - Purpose: To evaluate radiotherapy (RT) and chemotherapy (CT) treatments of early-stage extranodal natural killer/T-cell lymphoma (ENKTL). Materials and Methods: Fifty-five patients with stage I or II ENKTL [n=39 (71%) and 16 (29%) patients, respectively] who were treated with RT between 1999 and 2013 were analyzed retrospectively. The median age was 54 years (range, 24–81). Patients were grouped by treatment modality as RT alone [n=19 (35%)], upfront CT plus RT [CT+RT, n=16 (29%)], and concurrent chemoradiotherapy [CCRT, n=20 (36%)]. The median RT dose was 48 Gy. Patient characteristics between each treatment group were well balanced. Patterns of failure and survival were analyzed. Results: The overall response rate after RT was 94.6%. Ten patients experienced distant failure, and seven experienced local failure comprising five in-field and two out-field failures. The local and distant failure rates in the RT-alone group were the same (16%). In the CT+RT group, the most common failure sites were local (19%). In the CCRT group, the most common failures were distant (25%). At a median follow-up of 56 months (range, 1–178 months), the 5-year overall survival (OS) and progression-free survival rates were 66% and 54%, respectively. The 5-year OS rate for the RT-alone and CT+RT groups were 76% and 69%, respectively, and the 2-year OS rate for the CCRT group was 62% (p=0.388). Conclusion: In the era of multimodal treatment for ENKTL, RT alone using advanced techniques should be considered for local disease control, whereas maintenance CT regimens should be considered for distant disease control.

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