The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics

Jinho Seo, Min Wook Kim, Kwang Hee Bae, Sang Chul Lee, Jaewhan Song, Eun Woo Lee

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Regulation of cell survival and death, including apoptosis and necroptosis, is important for normal development and tissue homeostasis, and disruption of these processes can cause cancer, inflammatory diseases, and degenerative diseases. Ubiquitination is a cellular process that induces proteasomal degradation by covalently attaching ubiquitin to the substrate protein. In addition to proteolytic ubiquitination, nonproteolytic ubiquitination, such as M1-linked and K63-linked ubiquitination, has been shown to be important in recent studies, which have demonstrated its function in cell signaling pathways that regulate inflammation and cell death pathways. In this review, we summarize the TRAIL- and TNF-induced death receptor signaling pathways along with recent advances in this field and illustrate how different types of ubiquitination control cell death and survival. In particular, we provide an overview of the different types of ubiquitination, target residues, and modifying enzymes, including E3 ligases and deubiquitinating enzymes. Given the relevance of these regulatory pathways in human disease, we hope that a better understanding of the regulatory mechanisms of cell death pathways will provide insights into and therapeutic strategies for related diseases.

Original languageEnglish
Pages (from-to)21-40
Number of pages20
JournalBiochemical Pharmacology
Volume162
DOIs
Publication statusPublished - 2019 Apr

Fingerprint

Ubiquitination
Cell death
Cell Death
Tissue homeostasis
Cell signaling
Death Domain Receptors
Ubiquitin-Protein Ligases
Cell Survival
Enzymes
Therapeutics
Ubiquitin
Cells
Apoptosis
Degradation
Homeostasis
Substrates
Inflammation
Proteins
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

Cite this

Seo, Jinho ; Kim, Min Wook ; Bae, Kwang Hee ; Lee, Sang Chul ; Song, Jaewhan ; Lee, Eun Woo. / The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics. In: Biochemical Pharmacology. 2019 ; Vol. 162. pp. 21-40.
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The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics. / Seo, Jinho; Kim, Min Wook; Bae, Kwang Hee; Lee, Sang Chul; Song, Jaewhan; Lee, Eun Woo.

In: Biochemical Pharmacology, Vol. 162, 04.2019, p. 21-40.

Research output: Contribution to journalReview article

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T1 - The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics

AU - Seo, Jinho

AU - Kim, Min Wook

AU - Bae, Kwang Hee

AU - Lee, Sang Chul

AU - Song, Jaewhan

AU - Lee, Eun Woo

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AB - Regulation of cell survival and death, including apoptosis and necroptosis, is important for normal development and tissue homeostasis, and disruption of these processes can cause cancer, inflammatory diseases, and degenerative diseases. Ubiquitination is a cellular process that induces proteasomal degradation by covalently attaching ubiquitin to the substrate protein. In addition to proteolytic ubiquitination, nonproteolytic ubiquitination, such as M1-linked and K63-linked ubiquitination, has been shown to be important in recent studies, which have demonstrated its function in cell signaling pathways that regulate inflammation and cell death pathways. In this review, we summarize the TRAIL- and TNF-induced death receptor signaling pathways along with recent advances in this field and illustrate how different types of ubiquitination control cell death and survival. In particular, we provide an overview of the different types of ubiquitination, target residues, and modifying enzymes, including E3 ligases and deubiquitinating enzymes. Given the relevance of these regulatory pathways in human disease, we hope that a better understanding of the regulatory mechanisms of cell death pathways will provide insights into and therapeutic strategies for related diseases.

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