The Schwann Cell as an Active Synaptic Partner

Sujin Hyung, Kyuhwan Jung, Sung Rae Cho, Noo Li Jeon

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


The schwann cells of the peripheral nervous system are indispensable for the formation, maintenance, and modulation of synapses over the life cycle. They not only recognize neuron-glia signaling molecules, but also secrete gliotransmitters. Through these processes, they regulate neuronal excitability and thus the release of neurotransmitters from the nerve terminal at the neuromuscular junction. Gliotransmitters strongly affect nerve communication, and their secretion is mainly triggered by synchronized Ca2+ signaling, implicating Ca2+ waves in synapse function. Reciprocally, neurotransmitters released during synaptic activity can evoke increases in intracellular Ca2+ levels. A reconsideration of the interplay between the two main types of cells in the nervous system is due, as the concept of nervous system activity comprising only neuron-neuron and neuron-muscle action has become untenable. A more precise understanding of the roles of schwann cells in nerve-muscle signaling is required.

Original languageEnglish
Pages (from-to)1123-1127
Number of pages5
Issue number10
Publication statusPublished - 2018 May 22

Bibliographical note

Funding Information:
This paper was supported by the National Research Foundation of Korea (NRF-2015R/A2A/A09005662 and 2016R1A4A1010796).

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry


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