TY - JOUR
T1 - The significance of c-erbB-2 overexpression and p53 expression in patients with axillary lymph node-negative breast cancer
T2 - A tissue microarray study
AU - Ko, Seung Sang
AU - Na, Youn Sun
AU - Yoon, Chan Seok
AU - Park, Ji Young
AU - Kim, Hye Sun
AU - Hur, Min Hee
AU - Lee, Hae Kyung
AU - Chun, Yi Kyung
AU - Kang, Sung Soo
AU - Park, Byeong Woo
AU - Lee, Jee Hyun
PY - 2007/4
Y1 - 2007/4
N2 - We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.
AB - We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.
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U2 - 10.1177/1066896906299124
DO - 10.1177/1066896906299124
M3 - Article
C2 - 17478762
AN - SCOPUS:34047260755
SN - 1066-8969
VL - 15
SP - 98
EP - 109
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 2
ER -
