The significance of c-erbB-2 overexpression and p53 expression in patients with axillary lymph node-negative breast cancer: A tissue microarray study

Seung Sang Ko, Youn Sun Na, Chan Seok Yoon, Ji Young Park, Hye Sun Kim, Min Hee Hur, Hae Kyung Lee, Yi Kyung Chun, Sung Soo Kang, Byeong Woo Park, Jee Hyun Lee

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Abstract

We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.

Original languageEnglish
Pages (from-to)98-109
Number of pages12
JournalInternational Journal of Surgical Pathology
Volume15
Issue number2
DOIs
Publication statusPublished - 2007 Apr 1

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All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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