The significance of repeat prostate biopsy for the detection of prostate cancer

Eun Ki Park, Won Jae Yang, Young Deuk Choi, Byung Ha Chung, Koon Ho Rha, Seung Choul Yang, Sang Yol Mah, Sung Joon Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To evaluate the results of serial prostate biopsy in men with elevated prostate-specific antigen (PSA) levels, where the initial biopsies were negative for cancer. Materials and methods: Between January 2000 and December 2003, 750 men with a serum PSA level of 4.0ng/ml or greater underwent transrectal ultrasound guided needle biopsy of the prostate, with 218 (29.1%) diagnosed as having prostate cancer. Of the other 532 men, 104 (19.5%), whose follow-up PSA level was persistently elevated beyond the normal range, underwent a second biopsy, with 26 (4.9%) undergoing third and subsequent biopsies for the same reason. The cancer detection rates after each biopsy session, and reliable predictors for prostate cancer after the 2nd biopsy in those whose PSA level was in the gray zone, were evaluated. Results: The cancer detection rates of the 1st, 2nd and 3rd biopsies were 29.1, 16.3 and 30.7%, respectively, with 10.3% of the prostate cancers detected in this study missed on the initial biopsy. The detection rate of the second biopsy in gray zone patients was 13.1%, which was comparable to the first biopsy result (12.7%) for the same range group. The median PSA, % free PSA and PSA density were significantly different between the prostate cancer and non-cancer groups after the second biopsy in gray zone patients (p < 0.05). Conclusions: 10.3% of the prostate cancers detected in this study were missed on the initial biopsy. The median PSA, % free PSA and PSA density are reliable predictors of prostate cancer after the second biopsy in gray zone patients.

Original languageEnglish
Pages (from-to)1268-1271
Number of pages4
JournalKorean Journal of Urology
Volume46
Issue number12
Publication statusPublished - 2005 Dec 1

Fingerprint

Prostate
Prostatic Neoplasms
Prostate-Specific Antigen
Biopsy
Neoplasms
Needle Biopsy
Reference Values

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Park, Eun Ki ; Yang, Won Jae ; Choi, Young Deuk ; Chung, Byung Ha ; Rha, Koon Ho ; Yang, Seung Choul ; Mah, Sang Yol ; Hong, Sung Joon. / The significance of repeat prostate biopsy for the detection of prostate cancer. In: Korean Journal of Urology. 2005 ; Vol. 46, No. 12. pp. 1268-1271.
@article{8d6c071c8d1e4370b4780d7d61bb8711,
title = "The significance of repeat prostate biopsy for the detection of prostate cancer",
abstract = "Purpose: To evaluate the results of serial prostate biopsy in men with elevated prostate-specific antigen (PSA) levels, where the initial biopsies were negative for cancer. Materials and methods: Between January 2000 and December 2003, 750 men with a serum PSA level of 4.0ng/ml or greater underwent transrectal ultrasound guided needle biopsy of the prostate, with 218 (29.1{\%}) diagnosed as having prostate cancer. Of the other 532 men, 104 (19.5{\%}), whose follow-up PSA level was persistently elevated beyond the normal range, underwent a second biopsy, with 26 (4.9{\%}) undergoing third and subsequent biopsies for the same reason. The cancer detection rates after each biopsy session, and reliable predictors for prostate cancer after the 2nd biopsy in those whose PSA level was in the gray zone, were evaluated. Results: The cancer detection rates of the 1st, 2nd and 3rd biopsies were 29.1, 16.3 and 30.7{\%}, respectively, with 10.3{\%} of the prostate cancers detected in this study missed on the initial biopsy. The detection rate of the second biopsy in gray zone patients was 13.1{\%}, which was comparable to the first biopsy result (12.7{\%}) for the same range group. The median PSA, {\%} free PSA and PSA density were significantly different between the prostate cancer and non-cancer groups after the second biopsy in gray zone patients (p < 0.05). Conclusions: 10.3{\%} of the prostate cancers detected in this study were missed on the initial biopsy. The median PSA, {\%} free PSA and PSA density are reliable predictors of prostate cancer after the second biopsy in gray zone patients.",
author = "Park, {Eun Ki} and Yang, {Won Jae} and Choi, {Young Deuk} and Chung, {Byung Ha} and Rha, {Koon Ho} and Yang, {Seung Choul} and Mah, {Sang Yol} and Hong, {Sung Joon}",
year = "2005",
month = "12",
day = "1",
language = "English",
volume = "46",
pages = "1268--1271",
journal = "Korean Journal of Urology",
issn = "2005-6737",
publisher = "Korean Urological Association",
number = "12",

}

Park, EK, Yang, WJ, Choi, YD, Chung, BH, Rha, KH, Yang, SC, Mah, SY & Hong, SJ 2005, 'The significance of repeat prostate biopsy for the detection of prostate cancer', Korean Journal of Urology, vol. 46, no. 12, pp. 1268-1271.

The significance of repeat prostate biopsy for the detection of prostate cancer. / Park, Eun Ki; Yang, Won Jae; Choi, Young Deuk; Chung, Byung Ha; Rha, Koon Ho; Yang, Seung Choul; Mah, Sang Yol; Hong, Sung Joon.

In: Korean Journal of Urology, Vol. 46, No. 12, 01.12.2005, p. 1268-1271.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The significance of repeat prostate biopsy for the detection of prostate cancer

AU - Park, Eun Ki

AU - Yang, Won Jae

AU - Choi, Young Deuk

AU - Chung, Byung Ha

AU - Rha, Koon Ho

AU - Yang, Seung Choul

AU - Mah, Sang Yol

AU - Hong, Sung Joon

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Purpose: To evaluate the results of serial prostate biopsy in men with elevated prostate-specific antigen (PSA) levels, where the initial biopsies were negative for cancer. Materials and methods: Between January 2000 and December 2003, 750 men with a serum PSA level of 4.0ng/ml or greater underwent transrectal ultrasound guided needle biopsy of the prostate, with 218 (29.1%) diagnosed as having prostate cancer. Of the other 532 men, 104 (19.5%), whose follow-up PSA level was persistently elevated beyond the normal range, underwent a second biopsy, with 26 (4.9%) undergoing third and subsequent biopsies for the same reason. The cancer detection rates after each biopsy session, and reliable predictors for prostate cancer after the 2nd biopsy in those whose PSA level was in the gray zone, were evaluated. Results: The cancer detection rates of the 1st, 2nd and 3rd biopsies were 29.1, 16.3 and 30.7%, respectively, with 10.3% of the prostate cancers detected in this study missed on the initial biopsy. The detection rate of the second biopsy in gray zone patients was 13.1%, which was comparable to the first biopsy result (12.7%) for the same range group. The median PSA, % free PSA and PSA density were significantly different between the prostate cancer and non-cancer groups after the second biopsy in gray zone patients (p < 0.05). Conclusions: 10.3% of the prostate cancers detected in this study were missed on the initial biopsy. The median PSA, % free PSA and PSA density are reliable predictors of prostate cancer after the second biopsy in gray zone patients.

AB - Purpose: To evaluate the results of serial prostate biopsy in men with elevated prostate-specific antigen (PSA) levels, where the initial biopsies were negative for cancer. Materials and methods: Between January 2000 and December 2003, 750 men with a serum PSA level of 4.0ng/ml or greater underwent transrectal ultrasound guided needle biopsy of the prostate, with 218 (29.1%) diagnosed as having prostate cancer. Of the other 532 men, 104 (19.5%), whose follow-up PSA level was persistently elevated beyond the normal range, underwent a second biopsy, with 26 (4.9%) undergoing third and subsequent biopsies for the same reason. The cancer detection rates after each biopsy session, and reliable predictors for prostate cancer after the 2nd biopsy in those whose PSA level was in the gray zone, were evaluated. Results: The cancer detection rates of the 1st, 2nd and 3rd biopsies were 29.1, 16.3 and 30.7%, respectively, with 10.3% of the prostate cancers detected in this study missed on the initial biopsy. The detection rate of the second biopsy in gray zone patients was 13.1%, which was comparable to the first biopsy result (12.7%) for the same range group. The median PSA, % free PSA and PSA density were significantly different between the prostate cancer and non-cancer groups after the second biopsy in gray zone patients (p < 0.05). Conclusions: 10.3% of the prostate cancers detected in this study were missed on the initial biopsy. The median PSA, % free PSA and PSA density are reliable predictors of prostate cancer after the second biopsy in gray zone patients.

UR - http://www.scopus.com/inward/record.url?scp=32944457444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32944457444&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:32944457444

VL - 46

SP - 1268

EP - 1271

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 12

ER -