The site of plaque rupture in native coronary arteries

A three-vessel intravascular ultrasound analysis

Myeongki Hong, Gary S. Mintz, Whan Lee Cheol, Bong Ki Lee, Tae Hyun Yang, Young Hak Kim, Jong Min Song, Ki Hoon Han, Duk Hyun Kang, Sang Sig Cheong, Jae Kwan Song, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

OBJECTIVES: We evaluated the axial location of plaque ruptures in native coronary arteries. BACKGROUND: It is clinically important to understand the potential sites of plaque rupture. METHODS: We performed three-vessel intravascular ultrasound (IVUS) examination in 392 patients; 231 had acute coronary syndrome (ACS) and 161 had stable angina pectoris (SAP). The IVUS detected plaque ruptures in 206 patients: 158 ACS patients and 48 SAP patients. The distance between each coronary plaque rupture segment and the respective coronary ostium was measured with motorized IVUS transducer pullback in all three coronary arteries. RESULTS: There were a total of 273 plaque ruptures in these 206 patients; 143 in the left anterior descending artery (LAD), 40 in the left circumflex artery (LCX), and 90 in the right coronary artery (RCA). There were 67 plaque ruptures in SAP patients and 206 in ACS patients; there were 197 culprit/target lesion plaque ruptures and 76 non-culprit/non-target lesion plaque ruptures. The LAD plaque ruptures were predominantly located between 10 and 40 mm from the LAD ostium (83%, 119 of 143). The LCX plaque ruptures were evenly distributed in the entire LCX tree. Most RCA plaque ruptures were located in segments between 10 and 40 mm (48%, 43 of 90) and in segments >70 mm from the ostium (32%, 29 of 90). CONCLUSIONS: Three-vessel IVUS imaging showed that plaque ruptures occurred mainly in proximal segments of the LAD (83% of LAD plaque rupture), the proximal and distal segments of the RCA (48% and 32% of RCA plaque ruptures, respectively), and the entire LCX.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of the American College of Cardiology
Volume46
Issue number2
DOIs
Publication statusPublished - 2005 Jul 19

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Rupture
Coronary Vessels
Arteries
Stable Angina
Acute Coronary Syndrome
Transducers
Ultrasonography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeongki ; Mintz, Gary S. ; Cheol, Whan Lee ; Lee, Bong Ki ; Yang, Tae Hyun ; Kim, Young Hak ; Song, Jong Min ; Han, Ki Hoon ; Kang, Duk Hyun ; Cheong, Sang Sig ; Song, Jae Kwan ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / The site of plaque rupture in native coronary arteries : A three-vessel intravascular ultrasound analysis. In: Journal of the American College of Cardiology. 2005 ; Vol. 46, No. 2. pp. 261-265.
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title = "The site of plaque rupture in native coronary arteries: A three-vessel intravascular ultrasound analysis",
abstract = "OBJECTIVES: We evaluated the axial location of plaque ruptures in native coronary arteries. BACKGROUND: It is clinically important to understand the potential sites of plaque rupture. METHODS: We performed three-vessel intravascular ultrasound (IVUS) examination in 392 patients; 231 had acute coronary syndrome (ACS) and 161 had stable angina pectoris (SAP). The IVUS detected plaque ruptures in 206 patients: 158 ACS patients and 48 SAP patients. The distance between each coronary plaque rupture segment and the respective coronary ostium was measured with motorized IVUS transducer pullback in all three coronary arteries. RESULTS: There were a total of 273 plaque ruptures in these 206 patients; 143 in the left anterior descending artery (LAD), 40 in the left circumflex artery (LCX), and 90 in the right coronary artery (RCA). There were 67 plaque ruptures in SAP patients and 206 in ACS patients; there were 197 culprit/target lesion plaque ruptures and 76 non-culprit/non-target lesion plaque ruptures. The LAD plaque ruptures were predominantly located between 10 and 40 mm from the LAD ostium (83{\%}, 119 of 143). The LCX plaque ruptures were evenly distributed in the entire LCX tree. Most RCA plaque ruptures were located in segments between 10 and 40 mm (48{\%}, 43 of 90) and in segments >70 mm from the ostium (32{\%}, 29 of 90). CONCLUSIONS: Three-vessel IVUS imaging showed that plaque ruptures occurred mainly in proximal segments of the LAD (83{\%} of LAD plaque rupture), the proximal and distal segments of the RCA (48{\%} and 32{\%} of RCA plaque ruptures, respectively), and the entire LCX.",
author = "Myeongki Hong and Mintz, {Gary S.} and Cheol, {Whan Lee} and Lee, {Bong Ki} and Yang, {Tae Hyun} and Kim, {Young Hak} and Song, {Jong Min} and Han, {Ki Hoon} and Kang, {Duk Hyun} and Cheong, {Sang Sig} and Song, {Jae Kwan} and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Hong, M, Mintz, GS, Cheol, WL, Lee, BK, Yang, TH, Kim, YH, Song, JM, Han, KH, Kang, DH, Cheong, SS, Song, JK, Kim, JJ, Park, SW & Park, SJ 2005, 'The site of plaque rupture in native coronary arteries: A three-vessel intravascular ultrasound analysis', Journal of the American College of Cardiology, vol. 46, no. 2, pp. 261-265. https://doi.org/10.1016/j.jacc.2005.03.067

The site of plaque rupture in native coronary arteries : A three-vessel intravascular ultrasound analysis. / Hong, Myeongki; Mintz, Gary S.; Cheol, Whan Lee; Lee, Bong Ki; Yang, Tae Hyun; Kim, Young Hak; Song, Jong Min; Han, Ki Hoon; Kang, Duk Hyun; Cheong, Sang Sig; Song, Jae Kwan; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: Journal of the American College of Cardiology, Vol. 46, No. 2, 19.07.2005, p. 261-265.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The site of plaque rupture in native coronary arteries

T2 - A three-vessel intravascular ultrasound analysis

AU - Hong, Myeongki

AU - Mintz, Gary S.

AU - Cheol, Whan Lee

AU - Lee, Bong Ki

AU - Yang, Tae Hyun

AU - Kim, Young Hak

AU - Song, Jong Min

AU - Han, Ki Hoon

AU - Kang, Duk Hyun

AU - Cheong, Sang Sig

AU - Song, Jae Kwan

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

PY - 2005/7/19

Y1 - 2005/7/19

N2 - OBJECTIVES: We evaluated the axial location of plaque ruptures in native coronary arteries. BACKGROUND: It is clinically important to understand the potential sites of plaque rupture. METHODS: We performed three-vessel intravascular ultrasound (IVUS) examination in 392 patients; 231 had acute coronary syndrome (ACS) and 161 had stable angina pectoris (SAP). The IVUS detected plaque ruptures in 206 patients: 158 ACS patients and 48 SAP patients. The distance between each coronary plaque rupture segment and the respective coronary ostium was measured with motorized IVUS transducer pullback in all three coronary arteries. RESULTS: There were a total of 273 plaque ruptures in these 206 patients; 143 in the left anterior descending artery (LAD), 40 in the left circumflex artery (LCX), and 90 in the right coronary artery (RCA). There were 67 plaque ruptures in SAP patients and 206 in ACS patients; there were 197 culprit/target lesion plaque ruptures and 76 non-culprit/non-target lesion plaque ruptures. The LAD plaque ruptures were predominantly located between 10 and 40 mm from the LAD ostium (83%, 119 of 143). The LCX plaque ruptures were evenly distributed in the entire LCX tree. Most RCA plaque ruptures were located in segments between 10 and 40 mm (48%, 43 of 90) and in segments >70 mm from the ostium (32%, 29 of 90). CONCLUSIONS: Three-vessel IVUS imaging showed that plaque ruptures occurred mainly in proximal segments of the LAD (83% of LAD plaque rupture), the proximal and distal segments of the RCA (48% and 32% of RCA plaque ruptures, respectively), and the entire LCX.

AB - OBJECTIVES: We evaluated the axial location of plaque ruptures in native coronary arteries. BACKGROUND: It is clinically important to understand the potential sites of plaque rupture. METHODS: We performed three-vessel intravascular ultrasound (IVUS) examination in 392 patients; 231 had acute coronary syndrome (ACS) and 161 had stable angina pectoris (SAP). The IVUS detected plaque ruptures in 206 patients: 158 ACS patients and 48 SAP patients. The distance between each coronary plaque rupture segment and the respective coronary ostium was measured with motorized IVUS transducer pullback in all three coronary arteries. RESULTS: There were a total of 273 plaque ruptures in these 206 patients; 143 in the left anterior descending artery (LAD), 40 in the left circumflex artery (LCX), and 90 in the right coronary artery (RCA). There were 67 plaque ruptures in SAP patients and 206 in ACS patients; there were 197 culprit/target lesion plaque ruptures and 76 non-culprit/non-target lesion plaque ruptures. The LAD plaque ruptures were predominantly located between 10 and 40 mm from the LAD ostium (83%, 119 of 143). The LCX plaque ruptures were evenly distributed in the entire LCX tree. Most RCA plaque ruptures were located in segments between 10 and 40 mm (48%, 43 of 90) and in segments >70 mm from the ostium (32%, 29 of 90). CONCLUSIONS: Three-vessel IVUS imaging showed that plaque ruptures occurred mainly in proximal segments of the LAD (83% of LAD plaque rupture), the proximal and distal segments of the RCA (48% and 32% of RCA plaque ruptures, respectively), and the entire LCX.

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DO - 10.1016/j.jacc.2005.03.067

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EP - 265

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

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