The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

Pratik Shah, Suk Won Choi, Riddhi Nagda, Reka Geczy, Seok Keun Cho, Yong Joo Bhang, Tae Hwan Kim, Tae Yang Song, Phil Hyu Lee, Ju Hee Kang, Peter Waaben Thulstrup, Morten Jannik Bjerrum, Il Lae Jung, Seong Wook Yang

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Abstract

The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

Original languageEnglish
Pages (from-to)20717-20722
Number of pages6
JournalNanoscale
Volume10
Issue number44
DOIs
Publication statusPublished - 2018 Nov 28

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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    Shah, P., Choi, S. W., Nagda, R., Geczy, R., Cho, S. K., Bhang, Y. J., Kim, T. H., Song, T. Y., Lee, P. H., Kang, J. H., Thulstrup, P. W., Bjerrum, M. J., Jung, I. L., & Yang, S. W. (2018). The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs. Nanoscale, 10(44), 20717-20722. https://doi.org/10.1039/c8nr06186f