The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets

Hassan Farhat, Joon Sang Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study aims at analyzing the shape change of red blood cells in the process of streaming through a capillary smaller than the red blood cell diameter. The characteristics of its shape change and velocity can potentially lead to an indicator of a variety of diseases. We approach this problem with considering red blood cells as surfactant covered droplets. This assumption is justified by the fact that the cell membrane liquefies under high pressure in small capillaries, and this allows the marginalization of the mechanical properties of the membrane. The red blood cell membrane is in fact a macrocolloid containing lipid surfactant. When liquefied, it can be treated as a droplet of immiscible hemoglobin covered with lipid surfactant in plasma surrounding. The merit is to analyze the effect of the flow condition and domain geometry on the surfactant concentration change over the droplet interface, and the effect of this change on the surface tension of the droplet. The distribution of the surfactant is calculated by enforcing conservation of the surfactant mass concentration on the interface, leading to a convection diffusion equation. The equation takes account of the effects of the normal and Marangoni stresses as a boundary condition on the interface between the immiscible fluids. The gradient in the surface tension adversely determines the droplet shape by effecting a local change in the capillary number, and influences its velocity by retarding the local surface velocity. The choice of the Gunstensen model is motivated by its capability of handling incompressible fluids, and the locality of the application of the surface tension. We used the same concept to investigate the dynamic shape change of the RBC while flowing through the microvasculature, and explore the physics of the Fahraeus, and the Fahraeus-Lindqvist effects.

Original languageEnglish
Title of host publicationProceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages101-108
Number of pages8
Volume14
ISBN (Print)9780791843871
DOIs
Publication statusPublished - 2010 Jan 1
Event2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009 - Lake Buena Vista, FL, United States
Duration: 2009 Nov 132009 Nov 19

Other

Other2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009
CountryUnited States
CityLake Buena Vista, FL
Period09/11/1309/11/19

Fingerprint

Surface active agents
Blood
Surface tension
Cells
Cell membranes
Lipids
Fluids
Hemoglobin
Conservation
Physics
Boundary conditions
Membranes
Plasmas
Mechanical properties
Geometry

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

Cite this

Farhat, H., & Lee, J. S. (2010). The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009 (Vol. 14, pp. 101-108). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2009-12629
Farhat, Hassan ; Lee, Joon Sang. / The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets. Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. Vol. 14 American Society of Mechanical Engineers (ASME), 2010. pp. 101-108
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Farhat, H & Lee, JS 2010, The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets. in Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. vol. 14, American Society of Mechanical Engineers (ASME), pp. 101-108, 2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009, Lake Buena Vista, FL, United States, 09/11/13. https://doi.org/10.1115/IMECE2009-12629

The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets. / Farhat, Hassan; Lee, Joon Sang.

Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. Vol. 14 American Society of Mechanical Engineers (ASME), 2010. p. 101-108.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Farhat H, Lee JS. The study of RBC deformation in capillaries with a lattice boltzmann method for surfactant covered-droplets. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. Vol. 14. American Society of Mechanical Engineers (ASME). 2010. p. 101-108 https://doi.org/10.1115/IMECE2009-12629