The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al

Bogdan Šolaja; Miodrag Crossed D Signermanović; Dong Min Lim; Young Ki Paik

The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al

Bogdan Šolaja, Miodrag Crossed D Signermanović, Dong Min Lim, Young Ki Paik

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC₅₀ = 90 μM on sterol 14-reductase.

Original language	English
Pages (from-to)	1113-1116
Number of pages	4
Journal	Journal of the Serbian Chemical Society
Volume	61
Issue number	11
Publication status	Published - 1996

All Science Journal Classification (ASJC) codes

Chemistry(all)

Cite this

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title = "The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al",

abstract = "The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.",

author = "Bogdan {\v S}olaja and {Crossed D Signermanovi{\'c}}, Miodrag and Lim, {Dong Min} and Paik, {Young Ki}",

year = "1996",

language = "English",

volume = "61",

pages = "1113--1116",

journal = "Journal of the Serbian Chemical Society",

issn = "0352-5139",

publisher = "Serbian Chemical Society",

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T1 - The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al

AU - Šolaja, Bogdan

AU - Crossed D Signermanović, Miodrag

AU - Lim, Dong Min

AU - Paik, Young Ki

PY - 1996

Y1 - 1996

N2 - The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.

AB - The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.

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M3 - Article

AN - SCOPUS:4244175165

SN - 0352-5139

VL - 61

SP - 1113

EP - 1116

JO - Journal of the Serbian Chemical Society

JF - Journal of the Serbian Chemical Society

IS - 11

ER -

The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al

Abstract

All Science Journal Classification (ASJC) codes

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