The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.
|Number of pages||4|
|Journal||Journal of the Serbian Chemical Society|
|Publication status||Published - 1996 Jan 1|
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