The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al

Bogdan Šolaja, Miodrag Crossed D Signermanović, Dong Min Lim, Young Ki Paik

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Abstract

The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.

Original languageEnglish
Pages (from-to)1113-1116
Number of pages4
JournalJournal of the Serbian Chemical Society
Volume61
Issue number11
Publication statusPublished - 1996 Jan 1

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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