The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

Jogeswar Gadi, Seung Hyun Jung, Min Jung Lee, Ajita Jami, Kalyani Ruthala, Kyoung Min Kim, Nam Hoon Cho, Han Sung Jung, Cheol Hee Kim, Sung Kil Lim

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25 Citations (Scopus)


Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.

Original languageEnglish
Pages (from-to)25400-25413
Number of pages14
JournalJournal of Biological Chemistry
Issue number35
Publication statusPublished - 2013 Aug 30


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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