The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

Jogeswar Gadi, Seung Hyun Jung, Min Jung Lee, Ajita Jami, Kalyani Ruthala, Kyoung Min Kim, Namhoon Cho, Hansung Jung, Cheol Hee Kim, Sungkil Lim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.

Original languageEnglish
Pages (from-to)25400-25413
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
Publication statusPublished - 2013 Aug 30

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Osteoblasts
Osteogenesis
Transcription Factors
Genes
Defects
Proteins
Up-Regulation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Gadi, Jogeswar ; Jung, Seung Hyun ; Lee, Min Jung ; Jami, Ajita ; Ruthala, Kalyani ; Kim, Kyoung Min ; Cho, Namhoon ; Jung, Hansung ; Kim, Cheol Hee ; Lim, Sungkil. / The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 35. pp. 25400-25413.
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The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. / Gadi, Jogeswar; Jung, Seung Hyun; Lee, Min Jung; Jami, Ajita; Ruthala, Kalyani; Kim, Kyoung Min; Cho, Namhoon; Jung, Hansung; Kim, Cheol Hee; Lim, Sungkil.

In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25400-25413.

Research output: Contribution to journalArticle

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AU - Ruthala, Kalyani

AU - Kim, Kyoung Min

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AU - Lim, Sungkil

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