Abstract
Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.
| Original language | English |
|---|---|
| Pages (from-to) | 25400-25413 |
| Number of pages | 14 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 35 |
| DOIs | |
| Publication status | Published - 2013 Aug 30 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
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The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. / Gadi, Jogeswar; Jung, Seung Hyun; Lee, Min Jung; Jami, Ajita; Ruthala, Kalyani; Kim, Kyoung Min; Cho, Nam Hoon; Jung, Han Sung; Kim, Cheol Hee; Lim, Sung Kil.
In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25400-25413.Research output: Contribution to journal › Article
TY - JOUR
T1 - The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors
AU - Gadi, Jogeswar
AU - Jung, Seung Hyun
AU - Lee, Min Jung
AU - Jami, Ajita
AU - Ruthala, Kalyani
AU - Kim, Kyoung Min
AU - Cho, Nam Hoon
AU - Jung, Han Sung
AU - Kim, Cheol Hee
AU - Lim, Sung Kil
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.
AB - Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.
UR - http://www.scopus.com/inward/record.url?scp=84883375134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883375134&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.413377
DO - 10.1074/jbc.M112.413377
M3 - Article
C2 - 23888050
AN - SCOPUS:84883375134
VL - 288
SP - 25400
EP - 25413
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 35
ER -