The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

Jogeswar Gadi; Seung Hyun Jung; Min Jung Lee; Ajita Jami; Kalyani Ruthala; Kyoung Min Kim; Nam Hoon Cho; Han Sung Jung; Cheol Hee Kim; Sung Kil Lim

doi:10.1074/jbc.M112.413377

The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

Jogeswar Gadi, Seung Hyun Jung, Min Jung Lee, Ajita Jami, Kalyani Ruthala, Kyoung Min Kim, Nam Hoon Cho, Han Sung Jung, Cheol Hee Kim, Sung Kil Lim

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.

Original language	English
Pages (from-to)	25400-25413
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M112.413377
Publication status	Published - 2013 Aug 30

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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Gadi, J., Jung, S. H., Lee, M. J., Jami, A., Ruthala, K., Kim, K. M., Cho, N. H., Jung, H. S., Kim, C. H., & Lim, S. K. (2013). The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. Journal of Biological Chemistry, 288(35), 25400-25413. https://doi.org/10.1074/jbc.M112.413377

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title = "The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors",

abstract = "Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.",

author = "Jogeswar Gadi and Jung, {Seung Hyun} and Lee, {Min Jung} and Ajita Jami and Kalyani Ruthala and Kim, {Kyoung Min} and Cho, {Nam Hoon} and Jung, {Han Sung} and Kim, {Cheol Hee} and Lim, {Sung Kil}",

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doi = "10.1074/jbc.M112.413377",

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Gadi, J, Jung, SH, Lee, MJ, Jami, A, Ruthala, K, Kim, KM, Cho, NH , Jung, HS, Kim, CH & Lim, SK 2013, 'The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors', Journal of Biological Chemistry, vol. 288, no. 35, pp. 25400-25413. https://doi.org/10.1074/jbc.M112.413377

The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. / Gadi, Jogeswar; Jung, Seung Hyun; Lee, Min Jung et al.

In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25400-25413.

Research output: Contribution to journal › Article › peer-review

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T1 - The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

AU - Gadi, Jogeswar

AU - Jung, Seung Hyun

AU - Lee, Min Jung

AU - Jami, Ajita

AU - Ruthala, Kalyani

AU - Kim, Kyoung Min

AU - Cho, Nam Hoon

AU - Jung, Han Sung

AU - Kim, Cheol Hee

AU - Lim, Sung Kil

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.

AB - Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.

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SN - 0021-9258

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The transcription factor protein sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors

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