Abstract
Background: Sox11 deletion mice exhibit developmental defects, yet the detailed roles of Sox11 in osteogenesis are unknown. Results: Sox11 stimulated proliferation and survival of mesenchymal and osteoblast precursor cells through up-regulation of Tead2, as well as stimulated osteogenesis via Runx2 and Osterix. Conclusion: Sox11 positively regulates osteogenesis. Significance: Novel functions of Sox11 and its target genes during osteogenesis were established.
Original language | English |
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Pages (from-to) | 25400-25413 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 35 |
DOIs | |
Publication status | Published - 2013 Aug 30 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology