The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

Hye Min Park; Hye Sun Lee; Yong Jae Lee; Jun Hyuk Lee

doi:10.1016/j.diabres.2021.109042

The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

Hye Min Park, Hye Sun Lee, Yong Jae Lee, Jun Hyuk Lee

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Aims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628–0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521–0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.

Original language	English
Article number	109042
Journal	Diabetes Research and Clinical Practice
Volume	180
DOIs	https://doi.org/10.1016/j.diabres.2021.109042
Publication status	Published - 2021 Oct

Bibliographical note

Funding Information:
Data in this study were from the Korean Genome and Epidemiology Study (KoGES; 4851-302), National Research Institute of Health, Centers for Disease Control and Prevention, Ministry for Health and Welfare, Republic of Korea. All authors read and approved the final version of the manuscript. All authors read the journal's authorship agreement. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. All authors (Hye Min Park, Hye Sun Lee, Yong-Jae Lee, and Jun-Hyuk Lee) certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, or writing of the manuscript.

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2021.109042

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@article{72179621b53941598fd0db6eb164d11c,

title = "The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance",

abstract = "Aims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628–0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521–0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.",

author = "Park, {Hye Min} and Lee, {Hye Sun} and Lee, {Yong Jae} and Lee, {Jun Hyuk}",

note = "Funding Information: Data in this study were from the Korean Genome and Epidemiology Study (KoGES; 4851-302), National Research Institute of Health, Centers for Disease Control and Prevention, Ministry for Health and Welfare, Republic of Korea. All authors read and approved the final version of the manuscript. All authors read the journal's authorship agreement. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. All authors (Hye Min Park, Hye Sun Lee, Yong-Jae Lee, and Jun-Hyuk Lee) certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, or writing of the manuscript. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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doi = "10.1016/j.diabres.2021.109042",

language = "English",

volume = "180",

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The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance. / Park, Hye Min; Lee, Hye Sun; Lee, Yong Jae et al.

In: Diabetes Research and Clinical Practice, Vol. 180, 109042, 10.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

AU - Park, Hye Min

AU - Lee, Hye Sun

AU - Lee, Yong Jae

AU - Lee, Jun Hyuk

N1 - Funding Information: Data in this study were from the Korean Genome and Epidemiology Study (KoGES; 4851-302), National Research Institute of Health, Centers for Disease Control and Prevention, Ministry for Health and Welfare, Republic of Korea. All authors read and approved the final version of the manuscript. All authors read the journal's authorship agreement. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. All authors (Hye Min Park, Hye Sun Lee, Yong-Jae Lee, and Jun-Hyuk Lee) certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, or writing of the manuscript. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/10

Y1 - 2021/10

N2 - Aims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628–0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521–0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.

AB - Aims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628–0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521–0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.

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JO - Diabetes Research and Clinical Practice

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The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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