The troy microneedle: A rapidly separating, dissolving microneedle formed by cyclic contact and drying on the pillar (CCDP)

Miroo Kim, Huisuk Yang, Suyong Kim, Chisong Lee, Hyungil Jung

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In dissolving microneedle (DMN)-mediated therapy, complete and rapid delivery of DMNs is critical for the desired efficacy. Traditional patch-based DMN delivery, however, may fail due to incomplete delivery from insufficient skin insertion or rapid separation of microneedles due to their strong bond to the backing film. Here, we introduce the Troy microneedle, which was created by cyclic contact and drying on the pillar (CCDP), and which enabled simultaneous complete and rapid delivery of DMN. This CCDP process could be flexibly repeated to achieve a specific desired drug dose in a DMN.We evaluated DMN separation using agarose gel, and the Troy microneedle achieved more complete and rapid separation than other, more deeply dipped DMN, primarily because of the Troy's minimal junction between the DMN and pillar. When Troy microneedles were applied to pig cadaver skin, it took only 15 s for over 90% of encapsulated rhodamine B to be delivered, compared to 2 h with application of a traditional DMN patch. In vivo skin penetration studies demonstrated rapid DMN-separation of Troy microneedles still in solid form before dissolution. The Troy microneedle overcomes critical issues associated with the low penetration efficiency of flat patch-based DMN and provides an innovative route for DMN-mediated therapy, combining patient convenience with the desire drug efficacy.

Original languageEnglish
Article numbere0136513
JournalPloS one
Volume10
Issue number8
DOIs
Publication statusPublished - 2015 Aug 26

Bibliographical note

Funding Information:
This work was supported by the R&D program of MSIP/COMPA [Title: Development of minimal pain multi-micro lancets for one-touch-smart diagnostic sensor]

Publisher Copyright:
© 2015 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint

Dive into the research topics of 'The troy microneedle: A rapidly separating, dissolving microneedle formed by cyclic contact and drying on the pillar (CCDP)'. Together they form a unique fingerprint.

Cite this