The Unfolded Protein Response (UPR) pathway in Cryptococcus

Seon Ah Cheon, Kwang Woo Jung, Yong Sun Bahn, Hyun Ah Kang

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Unique and evolutionarily conserved signaling pathways allow an organism to sense, respond to, and adapt to internal and external environmental cues at its biological niche. In eukaryotic cells, the unfolded protein response (UPR) pathway regulates endoplasmic reticulum (ER) homeostasis upon exposure to environmental changes causing ER stress. The UPR pathway of Cryptococcus neoformans, an opportunistic fungal pathogen, which causes life-threatening meningoencephalitis in immunocompromised individuals, consists of the evolutionarily conserved Ire1 kinase, a unique bZIP transcription factor, Hxl1, and the ER-resident molecular chaperone Kar2/BiP. Although the Cryptococcus UPR pathway regulates ER stress, antifungal drug resistance, and virulence in an Ire1/ Hxl1-dependent manner, Ire1 has Hxl1-independent roles in capsule biosynthesis and thermotolerance. In this review, we highlight the conserved and unique features of the Cryptococcus UPR pathway compared with other fungal UPR systems and its importance in the pathogenesis of cryptococcosis and discuss future challenges in this field.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalVirulence
Volume5
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Unfolded Protein Response
Cryptococcus
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Fungal Drug Resistance
Basic-Leucine Zipper Transcription Factors
Cryptococcosis
Cryptococcus neoformans
Meningoencephalitis
Fungal Proteins
Environmental Exposure
Eukaryotic Cells
Capsules
Cues
Virulence
Homeostasis
Phosphotransferases

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cheon, Seon Ah ; Jung, Kwang Woo ; Bahn, Yong Sun ; Kang, Hyun Ah. / The Unfolded Protein Response (UPR) pathway in Cryptococcus. In: Virulence. 2014 ; Vol. 5, No. 2. pp. 341-350.
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The Unfolded Protein Response (UPR) pathway in Cryptococcus. / Cheon, Seon Ah; Jung, Kwang Woo; Bahn, Yong Sun; Kang, Hyun Ah.

In: Virulence, Vol. 5, No. 2, 01.01.2014, p. 341-350.

Research output: Contribution to journalReview article

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