The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients

Korean data.

Won Ki Hong, Moonyoung Kim, Soonkoo Baik, Seung Yong Shin, Jung Min Kim, Yong Seok Kang, Yoo Li Lim, Young Ju Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Hyoun A. Kim, Hye Won Kang, Sang Ok Kwon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.

Original languageEnglish
Pages (from-to)370-375
Number of pages6
JournalClinical and molecular hepatology
Volume19
Issue number4
DOIs
Publication statusPublished - 2013 Jan 1

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Portal Hypertension
Liver
Venous Pressure
Fibrosis
ROC Curve
Elasticity Imaging Techniques
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Molecular Biology

Cite this

Hong, Won Ki ; Kim, Moonyoung ; Baik, Soonkoo ; Shin, Seung Yong ; Kim, Jung Min ; Kang, Yong Seok ; Lim, Yoo Li ; Kim, Young Ju ; Cho, Youn Zoo ; Hwang, Hye Won ; Lee, Jin Hyung ; Chae, Myeong Hun ; Kim, Hyoun A. ; Kang, Hye Won ; Kwon, Sang Ok. / The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients : Korean data. In: Clinical and molecular hepatology. 2013 ; Vol. 19, No. 4. pp. 370-375.
@article{2e9080f7b3114368896632152f8a6d86,
title = "The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data.",
abstract = "Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5{\%}, 73.7{\%}, 86.8{\%}, and 66.7{\%}, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9{\%}, 70.8{\%}, 80.6{\%}, and 73.9{\%}, respectively. LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.",
author = "Hong, {Won Ki} and Moonyoung Kim and Soonkoo Baik and Shin, {Seung Yong} and Kim, {Jung Min} and Kang, {Yong Seok} and Lim, {Yoo Li} and Kim, {Young Ju} and Cho, {Youn Zoo} and Hwang, {Hye Won} and Lee, {Jin Hyung} and Chae, {Myeong Hun} and Kim, {Hyoun A.} and Kang, {Hye Won} and Kwon, {Sang Ok}",
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doi = "10.3350/cmh.2013.19.4.370",
language = "English",
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Hong, WK, Kim, M, Baik, S, Shin, SY, Kim, JM, Kang, YS, Lim, YL, Kim, YJ, Cho, YZ, Hwang, HW, Lee, JH, Chae, MH, Kim, HA, Kang, HW & Kwon, SO 2013, 'The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data.', Clinical and molecular hepatology, vol. 19, no. 4, pp. 370-375. https://doi.org/10.3350/cmh.2013.19.4.370

The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients : Korean data. / Hong, Won Ki; Kim, Moonyoung; Baik, Soonkoo; Shin, Seung Yong; Kim, Jung Min; Kang, Yong Seok; Lim, Yoo Li; Kim, Young Ju; Cho, Youn Zoo; Hwang, Hye Won; Lee, Jin Hyung; Chae, Myeong Hun; Kim, Hyoun A.; Kang, Hye Won; Kwon, Sang Ok.

In: Clinical and molecular hepatology, Vol. 19, No. 4, 01.01.2013, p. 370-375.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients

T2 - Korean data.

AU - Hong, Won Ki

AU - Kim, Moonyoung

AU - Baik, Soonkoo

AU - Shin, Seung Yong

AU - Kim, Jung Min

AU - Kang, Yong Seok

AU - Lim, Yoo Li

AU - Kim, Young Ju

AU - Cho, Youn Zoo

AU - Hwang, Hye Won

AU - Lee, Jin Hyung

AU - Chae, Myeong Hun

AU - Kim, Hyoun A.

AU - Kang, Hye Won

AU - Kwon, Sang Ok

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.

AB - Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.

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