The Validity of Random Urine Specimen Albumin Measurement as a Screening Test for Diabetic Nephropathy

Churl Woo Ahn, Young Duk Song, Jung Ho Kim, Sung Kil Lim, Kyu Hyun Choi, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh

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To assess the validity of urine albumin concentration (UAC) and the urine albumin:creatine ratio (UACR) in a random urine specimen (RUS) for screening diabetic nephropathy in Korea, a total of 105 ambulatory diabetes mellitus patients (male:female, 52 : 53), ages 40-75 years (median 59 years) collected 105 RUSs after completing a timed 24 hour urine collection. Albumin was measured by immunonephelometry. According to the timed urinary albumin excretion rate (UAER) measured in the 24 hour collection (criterion standard), samples were classified as normoalbuminuric (UAER < 20 μg/min; n=50), microalbuminuric (UAER 20-200 μg/min; n=30), and macroalbuminuric (UAER > 200 μg/min; n=25). The receiver operating characteristics (ROC) curve of UAC and UACR in a RUS for screening of microalbuminuria (normo-and microalbuminuric samples; n=80) and macroalbuminuria (micro- and macroalbuminuric samples; n=55) were plotted. Pearson's coefficients of correlation of 24 hour UAER vs. UAC and UACR were 0.81 and 0.75, respectively (P < 0.001). The point of intersection with a 100%-to-100% diagonal for microalbuminuria were as follows: 31.0 mg/l for UAC and 32.5 mg/g for UACR; for macroalbuminuria 181 mg/l for UAC and 287.3 mg/g for UACR. The sensitivity and specificity of the cut-off points for microalbuminuria were 77% and 82% for UAC and 77% and 92% for UACR. The sensitivity and specificity of the cut-off points for macroalbuminuria were 84% and 90% for UAC and 88% and 90% for UACR. In present study, no difference was observed when comparing the performance of UAC and UACR based on a statistical comparison by McNemar test. The repeated measurements of UAC and UACR in the same individual were statistically similar and were correlated with each other. Based on these results, albumin measurements (UAC and UACR) in a RUS were considered as a valid test for screening diabetic nephropathy.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalYonsei medical journal
Issue number1
Publication statusPublished - 1999 Feb


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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