The value of delta neutrophil index in young infants with febrile urinary tract infection

Jung Won Lee, Seong Heon Kim, Se Jin Park, Keum Hwa Lee, Jae Hyon Park, Andreas Kronbichler, Michael Eisenhut, Ji Hong Kim, Jong Wook Lee, Jae Il Shin

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3 Citations (Scopus)

Abstract

Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95% CI 0.558-0.687, P < 0.01) as well as for CRP (0.731, 95% CI 0.673-0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95% CI 0.542-0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers.

Original languageEnglish
Article number41265
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Feb 7

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Urinary Tract Infections
Neutrophils
Fever
Vesico-Ureteral Reflux
Pyelonephritis
C-Reactive Protein
Succimer
Blood Sedimentation
ROC Curve
Area Under Curve
Leukocyte Count
Bacterial Infections
Granulocytes
Leukocytes
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • General

Cite this

Lee, Jung Won ; Kim, Seong Heon ; Park, Se Jin ; Lee, Keum Hwa ; Park, Jae Hyon ; Kronbichler, Andreas ; Eisenhut, Michael ; Kim, Ji Hong ; Lee, Jong Wook ; Shin, Jae Il. / The value of delta neutrophil index in young infants with febrile urinary tract infection. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95{\%} CI 0.558-0.687, P < 0.01) as well as for CRP (0.731, 95{\%} CI 0.673-0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95{\%} CI 0.542-0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers.",
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Lee, JW, Kim, SH, Park, SJ, Lee, KH, Park, JH, Kronbichler, A, Eisenhut, M, Kim, JH, Lee, JW & Shin, JI 2017, 'The value of delta neutrophil index in young infants with febrile urinary tract infection', Scientific reports, vol. 7, 41265. https://doi.org/10.1038/srep41265

The value of delta neutrophil index in young infants with febrile urinary tract infection. / Lee, Jung Won; Kim, Seong Heon; Park, Se Jin; Lee, Keum Hwa; Park, Jae Hyon; Kronbichler, Andreas; Eisenhut, Michael; Kim, Ji Hong; Lee, Jong Wook; Shin, Jae Il.

In: Scientific reports, Vol. 7, 41265, 07.02.2017.

Research output: Contribution to journalArticle

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