Abstract
It has been reported that mechanical properties of tissue-engineered cartilage were significantly lower than those of natural cartilage, even though many efforts have been made to regenerate high quality articular cartilage by tissue engineering techniques. Further studies must be conducted to find an optimal technique for regeneration of qualitative cartilage with the type of cells, extracellular matrices, growth factors, scaffolds, and bioreactors providing a proper mechanical stimulation. In this study, the effects of culture time and three different kinds of extra cellular matrixes (ECM) in two levels of density on the variation of stiffness (Young's modulus, E) of chondrocyte were evaluated by the cytoindentation technique. Compared with no ECM coating, all kinds of ECM coatings improved Young's modulus of chondrocyte. Type II collagen and fibronectin significantly increased the Young's modulus of chondrocyte after 4 h culture time. This suggested that the variations of biological environment affected the biomechanical property of chondrocyte. This result provided the valuable information to tissue engineering approaches for obtaining more improved biomechanical property of regenerated cartilage tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 493-496 |
| Number of pages | 4 |
| Journal | Current Applied Physics |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)
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The variation of biomechanical property of chondrocyte under the various biological conditions. / Park, Sang Guk; Lee, Kwon Yong; Shin, Daehwan; Park, Jongchul; Lee, Inseop; Lee, Heayoung.
In: Current Applied Physics, Vol. 5, No. 5, 01.07.2005, p. 493-496.Research output: Contribution to journal › Article
TY - JOUR
T1 - The variation of biomechanical property of chondrocyte under the various biological conditions
AU - Park, Sang Guk
AU - Lee, Kwon Yong
AU - Shin, Daehwan
AU - Park, Jongchul
AU - Lee, Inseop
AU - Lee, Heayoung
PY - 2005/7/1
Y1 - 2005/7/1
N2 - It has been reported that mechanical properties of tissue-engineered cartilage were significantly lower than those of natural cartilage, even though many efforts have been made to regenerate high quality articular cartilage by tissue engineering techniques. Further studies must be conducted to find an optimal technique for regeneration of qualitative cartilage with the type of cells, extracellular matrices, growth factors, scaffolds, and bioreactors providing a proper mechanical stimulation. In this study, the effects of culture time and three different kinds of extra cellular matrixes (ECM) in two levels of density on the variation of stiffness (Young's modulus, E) of chondrocyte were evaluated by the cytoindentation technique. Compared with no ECM coating, all kinds of ECM coatings improved Young's modulus of chondrocyte. Type II collagen and fibronectin significantly increased the Young's modulus of chondrocyte after 4 h culture time. This suggested that the variations of biological environment affected the biomechanical property of chondrocyte. This result provided the valuable information to tissue engineering approaches for obtaining more improved biomechanical property of regenerated cartilage tissue.
AB - It has been reported that mechanical properties of tissue-engineered cartilage were significantly lower than those of natural cartilage, even though many efforts have been made to regenerate high quality articular cartilage by tissue engineering techniques. Further studies must be conducted to find an optimal technique for regeneration of qualitative cartilage with the type of cells, extracellular matrices, growth factors, scaffolds, and bioreactors providing a proper mechanical stimulation. In this study, the effects of culture time and three different kinds of extra cellular matrixes (ECM) in two levels of density on the variation of stiffness (Young's modulus, E) of chondrocyte were evaluated by the cytoindentation technique. Compared with no ECM coating, all kinds of ECM coatings improved Young's modulus of chondrocyte. Type II collagen and fibronectin significantly increased the Young's modulus of chondrocyte after 4 h culture time. This suggested that the variations of biological environment affected the biomechanical property of chondrocyte. This result provided the valuable information to tissue engineering approaches for obtaining more improved biomechanical property of regenerated cartilage tissue.
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U2 - 10.1016/j.cap.2005.01.017
DO - 10.1016/j.cap.2005.01.017
M3 - Article
VL - 5
SP - 493
EP - 496
JO - Current Applied Physics
JF - Current Applied Physics
SN - 1567-1739
IS - 5
ER -