The variation of biomechanical property of chondrocyte under the various biological conditions

Sang Guk Park, Kwon Yong Lee, Daehwan Shin, Jongchul Park, Inseop Lee, Heayoung Lee

Research output: Contribution to journalArticle

Abstract

It has been reported that mechanical properties of tissue-engineered cartilage were significantly lower than those of natural cartilage, even though many efforts have been made to regenerate high quality articular cartilage by tissue engineering techniques. Further studies must be conducted to find an optimal technique for regeneration of qualitative cartilage with the type of cells, extracellular matrices, growth factors, scaffolds, and bioreactors providing a proper mechanical stimulation. In this study, the effects of culture time and three different kinds of extra cellular matrixes (ECM) in two levels of density on the variation of stiffness (Young's modulus, E) of chondrocyte were evaluated by the cytoindentation technique. Compared with no ECM coating, all kinds of ECM coatings improved Young's modulus of chondrocyte. Type II collagen and fibronectin significantly increased the Young's modulus of chondrocyte after 4 h culture time. This suggested that the variations of biological environment affected the biomechanical property of chondrocyte. This result provided the valuable information to tissue engineering approaches for obtaining more improved biomechanical property of regenerated cartilage tissue.

Original languageEnglish
Pages (from-to)493-496
Number of pages4
JournalCurrent Applied Physics
Volume5
Issue number5
DOIs
Publication statusPublished - 2005 Jul 1

Fingerprint

cartilage
Cartilage
modulus of elasticity
tissue engineering
Elastic moduli
matrices
Tissue engineering
Tissue
bioreactors
coatings
Coatings
Collagen Type II
collagens
Bioreactors
regeneration
stimulation
Fibronectins
Collagen
Scaffolds
stiffness

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Park, Sang Guk ; Lee, Kwon Yong ; Shin, Daehwan ; Park, Jongchul ; Lee, Inseop ; Lee, Heayoung. / The variation of biomechanical property of chondrocyte under the various biological conditions. In: Current Applied Physics. 2005 ; Vol. 5, No. 5. pp. 493-496.
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The variation of biomechanical property of chondrocyte under the various biological conditions. / Park, Sang Guk; Lee, Kwon Yong; Shin, Daehwan; Park, Jongchul; Lee, Inseop; Lee, Heayoung.

In: Current Applied Physics, Vol. 5, No. 5, 01.07.2005, p. 493-496.

Research output: Contribution to journalArticle

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