The Wnt pathway and the roles for its antagonists, DKKS, in angiogenesis

Hyun Jung Choi, Hongryeol Park, Heon Woo Lee, Young Guen Kwon

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

The Wnt signaling pathway is involved in a wide range of developmental and physiological processes, such as cell fate specification, tissue morphogenesis, and homeostasis. Thus, its dysregulation has been found in multiple diseases, including some cardiovascular disorders. The loss or gain of function of Wnt pathway components results in abnormal vascular development and angiogenesis. Further study has revealed that Wnt signaling in endothelial cells appears to contribute to vascular morphogenesis and endothelial cell specification. Owing to the significance of Wnt signaling in angiogenesis, Wnt antagonists have been considered potential treatments for neovascular disorders. In line with this, members of the Dkk protein family (Dkks), well-known Wnt antagonists, have been recently found to regulate angiogenesis. This review summarizes our present knowledge of the roles of Wnt signaling and Wnt antagonists, particularly Dkks, in angiogenic regulation and explores the therapeutic potential of Wnt antagonists. © 2012 IUBMB IUBMB Life, 64(9): 724-731, 2012

Original languageEnglish
Pages (from-to)724-731
Number of pages8
JournalIUBMB Life
Volume64
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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