The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer: outcomes of a propensity score-matched analysis

Sung Hwan Lee, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.

Original languageEnglish
Pages (from-to)4656-4664
Number of pages9
JournalSurgical endoscopy
Volume31
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

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Propensity Score
Pancreatic Neoplasms
Pancreatectomy
Survival
ROC Curve
Disease-Free Survival
Area Under Curve
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

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title = "The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer: outcomes of a propensity score-matched analysis",
abstract = "Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.",
author = "Lee, {Sung Hwan} and Hwang, {Ho Kyoung} and Kang, {Chang Moo} and Lee, {Woo Jung}",
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The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer : outcomes of a propensity score-matched analysis. / Lee, Sung Hwan; Hwang, Ho Kyoung; Kang, Chang Moo; Lee, Woo Jung.

In: Surgical endoscopy, Vol. 31, No. 11, 01.11.2017, p. 4656-4664.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer

T2 - outcomes of a propensity score-matched analysis

AU - Lee, Sung Hwan

AU - Hwang, Ho Kyoung

AU - Kang, Chang Moo

AU - Lee, Woo Jung

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.

AB - Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.

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SN - 0930-2794

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