Abstract
Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.
| Original language | English |
|---|---|
| Pages (from-to) | 4656-4664 |
| Number of pages | 9 |
| Journal | Surgical endoscopy |
| Volume | 31 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2017 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
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The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer : outcomes of a propensity score-matched analysis. / Lee, Sung Hwan; Hwang, Ho Kyoung; Kang, Chang Moo; Lee, Woo Jung.
In: Surgical endoscopy, Vol. 31, No. 11, 01.11.2017, p. 4656-4664.Research output: Contribution to journal › Article
TY - JOUR
T1 - The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer
T2 - outcomes of a propensity score-matched analysis
AU - Lee, Sung Hwan
AU - Hwang, Ho Kyoung
AU - Kang, Chang Moo
AU - Lee, Woo Jung
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.
AB - Background: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. Methods: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively. Results: Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients’ survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable. Conclusions: Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.
UR - http://www.scopus.com/inward/record.url?scp=85017156415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017156415&partnerID=8YFLogxK
U2 - 10.1007/s00464-017-5529-6
DO - 10.1007/s00464-017-5529-6
M3 - Article
C2 - 28389802
AN - SCOPUS:85017156415
VL - 31
SP - 4656
EP - 4664
JO - Surgical Endoscopy
JF - Surgical Endoscopy
SN - 0930-2794
IS - 11
ER -