Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors

Sumit Barua, Jong Youl Kim, Jae Young Kim, Jae Hwan Kim, Jong Eun Lee

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is related to abnormal biochemical and electrical signals in the brain cells. As a result, ion channels and receptors that are abundant in the nervous system and control the electrical and biochemical environment of the CNS play a vital role in neurological disease. The N-methyl-d-aspartate receptor, 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptor, kainate receptor, acetylcholine receptor, serotonin receptor, α2-adrenoreceptor, and acid-sensing ion channels are among the major channels and receptors known to be key components of pathophysiological events in the CNS. The primary amine agmatine, a neuromodulator synthesized in the brain by decarboxylation of l-arginine, can regulate ion channel cascades and receptors that are related to the major CNS disorders. In our previous studies, we established that agmatine was related to the regulation of cell differentiation, nitric oxide synthesis, and murine brain endothelial cell migration, relief of chronic pain, cerebral edema, and apoptotic cell death in experimental CNS disorders. In this review, we will focus on the pathophysiological aspects of the neurological disorders regulated by these ion channels and receptors, and their interaction with agmatine in CNS injury.

Original languageEnglish
Pages (from-to)735-750
Number of pages16
JournalNeurochemical Research
Issue number4
Publication statusPublished - 2019 Apr 1

Bibliographical note

Funding Information:
This study was supported by National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (2017R1A2B2005350).

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors'. Together they form a unique fingerprint.

Cite this