Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation

Hye Jin Kim, Shin Ae Kang, Taisoon Yong, Myeong Heon Shin, Kyu Jae Lee, Gab Man Park, Uktamjon Suvonkulov, Hak Sun Yu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4 + CD25 + Foxp3 + T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4 + CD4 + T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalExperimental Parasitology
Volume198
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Echinococcus granulosus
Therapeutic Uses
Inflammation
Regulatory T-Lymphocytes
Airway Resistance
Immune System Diseases
Ovalbumin
Bronchoalveolar Lavage Fluid
Aluminum
Inbred C57BL Mouse
Eosinophils
Interleukin-4
Spleen
Animal Models
Cell Count
Lymph Nodes
Cytokines
T-Lymphocytes
Lung
Therapeutics

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases

Cite this

Kim, Hye Jin ; Kang, Shin Ae ; Yong, Taisoon ; Shin, Myeong Heon ; Lee, Kyu Jae ; Park, Gab Man ; Suvonkulov, Uktamjon ; Yu, Hak Sun. / Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation. In: Experimental Parasitology. 2019 ; Vol. 198. pp. 63-70.
@article{7a817aac1d4f46339dc0d7477b7e3143,
title = "Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation",
abstract = "Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4 + CD25 + Foxp3 + T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4 + CD4 + T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.",
author = "Kim, {Hye Jin} and Kang, {Shin Ae} and Taisoon Yong and Shin, {Myeong Heon} and Lee, {Kyu Jae} and Park, {Gab Man} and Uktamjon Suvonkulov and Yu, {Hak Sun}",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.exppara.2019.02.003",
language = "English",
volume = "198",
pages = "63--70",
journal = "Experimental Parasitology",
issn = "0014-4894",
publisher = "Academic Press Inc.",

}

Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation. / Kim, Hye Jin; Kang, Shin Ae; Yong, Taisoon; Shin, Myeong Heon; Lee, Kyu Jae; Park, Gab Man; Suvonkulov, Uktamjon; Yu, Hak Sun.

In: Experimental Parasitology, Vol. 198, 01.03.2019, p. 63-70.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation

AU - Kim, Hye Jin

AU - Kang, Shin Ae

AU - Yong, Taisoon

AU - Shin, Myeong Heon

AU - Lee, Kyu Jae

AU - Park, Gab Man

AU - Suvonkulov, Uktamjon

AU - Yu, Hak Sun

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4 + CD25 + Foxp3 + T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4 + CD4 + T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.

AB - Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4 + CD25 + Foxp3 + T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4 + CD4 + T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.

UR - http://www.scopus.com/inward/record.url?scp=85061528319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061528319&partnerID=8YFLogxK

U2 - 10.1016/j.exppara.2019.02.003

DO - 10.1016/j.exppara.2019.02.003

M3 - Article

C2 - 30763570

AN - SCOPUS:85061528319

VL - 198

SP - 63

EP - 70

JO - Experimental Parasitology

JF - Experimental Parasitology

SN - 0014-4894

ER -