Therapeutic efficacy of curcumin enhanced by microscale discoidal polymeric particles in a murine asthma model

Jun Young Park, Ga Eul Chu, Sanghyo Park, Chaewon Park, Susmita Aryal, Won Jun Kang, Won Gil Cho, Jaehong Key

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-co-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 µm and a zeta potential value of −34.6 ± 4.8 mV. Ex vivo biodistribution results showed that the Cur-PLGA-DPPs mainly accumulated in the lungs and liver after intravenous injection. Treatment with Cur-PLGA-DPPs effectively suppressed the infiltration of inflammatory cells in bronchoalveolar lavage fluid, and reduced bronchial wall thickening and goblet-cell hyperplasia compared to those in the phosphate-buffered-saline-treated control group. No significant changes in hematology and blood biochemistry parameters were observed after treatment with Cur-PLGA-DPPs. At equal curcumin concentrations, treatment with Cur-PLGA-DPPs exhibited better therapeutic efficacy than treatment with free curcumin. Our results suggest that the microscale Cur-PLGA-DPPs can be potentially used as a lung-targeted asthma therapy.

Original languageEnglish
Article number739
Pages (from-to)1-14
Number of pages14
JournalPharmaceutics
Volume12
Issue number8
DOIs
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This research was funded by National Research Foundation of Korea (NRF), grant numbers 2017R1A5A2015369, 2018R1D1A1B07042339, and 2019K2A9A2A08000123. Also, the following are the results of a study on the ?Leaders in Industry-university Cooperation +? Project, supported by the Ministry of Education and National Research Foundation of Korea. The authors would like to thank Dong-Su Jang, MFA (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea), for his help with the illustrations and Ji Hae Nahm (Department of Pathology, Yonsei University College of Medicine, Seoul, Korea) for her valuable assistance with the histological analysis.

Funding Information:
Funding: This research was funded by National Research Foundation of Korea (NRF), grant numbers 2017R1A5A2015369, 2018R1D1A1B07042339, and 2019K2A9A2A08000123. Also, the following are the results of a study on the “Leaders in Industry-university Cooperation +” Project, supported by the Ministry of Education and National Research Foundation of Korea.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Therapeutic efficacy of curcumin enhanced by microscale discoidal polymeric particles in a murine asthma model'. Together they form a unique fingerprint.

Cite this