Therapeutic efficacy of curcumin enhanced by microscale discoidal polymeric particles in a murine asthma model

Jun Young Park, Ga Eul Chu, Sanghyo Park, Chaewon Park, Susmita Aryal, Won Jun Kang, Won Gil Cho, Jaehong Key

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-co-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 µm and a zeta potential value of −34.6 ± 4.8 mV. Ex vivo biodistribution results showed that the Cur-PLGA-DPPs mainly accumulated in the lungs and liver after intravenous injection. Treatment with Cur-PLGA-DPPs effectively suppressed the infiltration of inflammatory cells in bronchoalveolar lavage fluid, and reduced bronchial wall thickening and goblet-cell hyperplasia compared to those in the phosphate-buffered-saline-treated control group. No significant changes in hematology and blood biochemistry parameters were observed after treatment with Cur-PLGA-DPPs. At equal curcumin concentrations, treatment with Cur-PLGA-DPPs exhibited better therapeutic efficacy than treatment with free curcumin. Our results suggest that the microscale Cur-PLGA-DPPs can be potentially used as a lung-targeted asthma therapy.

Original languageEnglish
Article number739
Pages (from-to)1-14
Number of pages14
JournalPharmaceutics
Volume12
Issue number8
DOIs
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
Funding: This research was funded by National Research Foundation of Korea (NRF), grant numbers 2017R1A5A2015369, 2018R1D1A1B07042339, and 2019K2A9A2A08000123. Also, the following are the results of a study on the “Leaders in Industry-university Cooperation +” Project, supported by the Ministry of Education and National Research Foundation of Korea.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Therapeutic efficacy of curcumin enhanced by microscale discoidal polymeric particles in a murine asthma model'. Together they form a unique fingerprint.

Cite this