Therapeutic implications of autophagy inducers in immunological disorders, infection, and cancer

Sanguine Byun, Eunjung Lee, Ki Won Lee

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Autophagy is an essential catabolic program that forms part of the stress response and enables cells to break down their own intracellular components within lysosomes for recycling. Accumulating evidence suggests that autophagy plays vital roles in determining pathological outcomes of immune responses and tumorigenesis. Autophagy regulates innate and adaptive immunity affecting the pathologies of infectious, inflammatory, and autoimmune diseases. In cancer, autophagy appears to play distinct roles depending on the context of the malignancy by either promoting or suppressing key determinants of cancer cell survival. This review covers recent developments in the understanding of autophagy and discusses potential therapeutic interventions that may alter the outcomes of certain diseases.

Original languageEnglish
Article numberA1959
JournalInternational journal of molecular sciences
Volume18
Issue number9
DOIs
Publication statusPublished - 2017 Sep 12

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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