Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)

Eunae Sandra Cho, Hee Eun Kang, Nam Hee Kim, Jong In Yook

Research output: Contribution to journalReview articlepeer-review

103 Citations (Scopus)

Abstract

The epithelial-mesenchymal transition (EMT) comprises an essential biological process involving cancer progression as well as initiation. While the EMT has been regarded as a phenotypic conversion from epithelial to mesenchymal cells, recent evidence indicates that it plays a critical role in stemness, metabolic reprogramming, immune evasion and therapeutic resistance of cancer cells. Interestingly, several transcriptional repressors including Snail (SNAI1), Slug (SNAI2) and the ZEB family constitute key players for EMT in cancer as well as in the developmental process. Note that the dynamic conversion between EMT and epithelial reversion (mesenchymal-epithelial transition, MET) occurs through variable intermediate-hybrid states rather than being a binary process. Given the close connection between oncogenic signaling and EMT repressors, the EMT has emerged as a therapeutic target or goal (in terms of MET reversion) in cancer therapy. Here we review the critical role of EMT in therapeutic resistance and the importance of EMT as a therapeutic target for human cancer.

Original languageEnglish
Pages (from-to)14-24
Number of pages11
JournalArchives of pharmacal research
Volume42
Issue number1
DOIs
Publication statusPublished - 2019 Jan 17

Bibliographical note

Funding Information:
We thank E. Tunkle for preparation of the manuscript. This work was supported by grants from the National Research Foundation of Korea (NRF-2017R1A2B3002241, NRF-2016R1E1A1A01942724, NRF-2014R1A6A3A04055110, NRF-2017R1C1B1012464) funded by the Korean government (MSIP) and a grant from the Korea Health Industry Development Institute (KHIDI) funded by the Ministry for Health & Welfare Korea (HI17C2586).

Publisher Copyright:
© 2019, The Author(s).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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