Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome

Euigeum Oh, So Youn Bang, Soo Hyun Kim, Sa Saeng Hyun, Sang Hui Chu, Justin Y. Jeon, Jee Aee Im, Jung Eun Lee, Mi Kyung Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective:The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS).Methods:The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1ß, interleukin-6, tumor necrosis factor-alpha (TNF-a), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program.Results:After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p <.05).Conclusion:These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalBiological Research for Nursing
Volume15
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Chemokine CCL2
Chemokines
Life Style
Therapeutics
C-Reactive Protein
Control Groups
Resistin
Retinol-Binding Proteins
Caloric Restriction
CD40 Ligand
Pulse Wave Analysis
Vascular Stiffness
Adiponectin
Endothelin-1
Therapeutic Uses
Leptin
Interleukin-1
Health Education
Ankle
Peroxidase

All Science Journal Classification (ASJC) codes

  • Research and Theory

Cite this

Oh, Euigeum ; Bang, So Youn ; Kim, Soo Hyun ; Hyun, Sa Saeng ; Chu, Sang Hui ; Jeon, Justin Y. ; Im, Jee Aee ; Lee, Jung Eun ; Lee, Mi Kyung. / Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome. In: Biological Research for Nursing. 2013 ; Vol. 15, No. 1. pp. 48-55.
@article{bfa837e7c2314e02a417a4d7407984f6,
title = "Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome",
abstract = "Objective:The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS).Methods:The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1{\ss}, interleukin-6, tumor necrosis factor-alpha (TNF-a), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program.Results:After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p <.05).Conclusion:These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.",
author = "Euigeum Oh and Bang, {So Youn} and Kim, {Soo Hyun} and Hyun, {Sa Saeng} and Chu, {Sang Hui} and Jeon, {Justin Y.} and Im, {Jee Aee} and Lee, {Jung Eun} and Lee, {Mi Kyung}",
year = "2013",
month = "1",
day = "1",
doi = "10.1177/1099800411416637",
language = "English",
volume = "15",
pages = "48--55",
journal = "Biological Research for Nursing",
issn = "1099-8004",
publisher = "SAGE Publications Inc.",
number = "1",

}

Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome. / Oh, Euigeum; Bang, So Youn; Kim, Soo Hyun; Hyun, Sa Saeng; Chu, Sang Hui; Jeon, Justin Y.; Im, Jee Aee; Lee, Jung Eun; Lee, Mi Kyung.

In: Biological Research for Nursing, Vol. 15, No. 1, 01.01.2013, p. 48-55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome

AU - Oh, Euigeum

AU - Bang, So Youn

AU - Kim, Soo Hyun

AU - Hyun, Sa Saeng

AU - Chu, Sang Hui

AU - Jeon, Justin Y.

AU - Im, Jee Aee

AU - Lee, Jung Eun

AU - Lee, Mi Kyung

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective:The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS).Methods:The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1ß, interleukin-6, tumor necrosis factor-alpha (TNF-a), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program.Results:After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p <.05).Conclusion:These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.

AB - Objective:The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS).Methods:The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1ß, interleukin-6, tumor necrosis factor-alpha (TNF-a), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program.Results:After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p <.05).Conclusion:These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.

UR - http://www.scopus.com/inward/record.url?scp=84869859035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869859035&partnerID=8YFLogxK

U2 - 10.1177/1099800411416637

DO - 10.1177/1099800411416637

M3 - Article

VL - 15

SP - 48

EP - 55

JO - Biological Research for Nursing

JF - Biological Research for Nursing

SN - 1099-8004

IS - 1

ER -