Therapeutic plasma exchange using the spectra optia cell separator compared with the COBE spectra

Do Kyun Kim, Sinyoung Kim, Seokhoon Jeong, Hyun Ok Kim, Hyung Jik Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety. Methods: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed. Results: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was 94.2±10.3 min in the SPO group and 100.4±11.2 min in the CSP group (P<0.001). The plasma removal efficiency (PRE) was 92.5±4.9% in the SPO group and 83.2±3.7% in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters. Conclusions: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures.

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalAnnals of laboratory medicine
Volume35
Issue number5
DOIs
Publication statusPublished - 2015 Sep 1

Fingerprint

Plasma Exchange
Separators
Plasmas
Transplants
Blood Component Removal
Plasma Volume
Kidney
Therapeutics
Demography
Graft Rejection
Retrospective Studies
Grafts
Safety
Antibodies

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kim, Do Kyun ; Kim, Sinyoung ; Jeong, Seokhoon ; Kim, Hyun Ok ; Kim, Hyung Jik. / Therapeutic plasma exchange using the spectra optia cell separator compared with the COBE spectra. In: Annals of laboratory medicine. 2015 ; Vol. 35, No. 5. pp. 506-509.
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Therapeutic plasma exchange using the spectra optia cell separator compared with the COBE spectra. / Kim, Do Kyun; Kim, Sinyoung; Jeong, Seokhoon; Kim, Hyun Ok; Kim, Hyung Jik.

In: Annals of laboratory medicine, Vol. 35, No. 5, 01.09.2015, p. 506-509.

Research output: Contribution to journalArticle

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