Therapeutic Potentials of Localized Blood-Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review

Amanda Cammalleri; Phillip Croce; Wonhye Lee; Kyungho Yoon; Seung Schik Yoo

doi:10.1097/WNP.0000000000000488

Therapeutic Potentials of Localized Blood-Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review

Amanda Cammalleri, Phillip Croce, Wonhye Lee, Kyungho Yoon, Seung Schik Yoo

School of Mathematics and Computing

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The demands for region-specific, noninvasive therapies for neurologic/psychiatric conditions are growing. The rise of transcranial focused ultrasound technology has witnessed temporary and reversible disruptions of the blood-brain barrier in the brain with exceptional control over the spatial precisions and depth, all in a noninvasive manner. Starting with small animal studies about a decade ago, the technique is now being explored in nonhuman primates and humans for the assessment of its efficacy and safety. The ability to transfer exogenous/endogenous therapeutic agents, cells, and biomolecules across the blood-brain barrier opens up new therapeutic avenues for various neurologic conditions, with a possibility to modulate the excitability of regional brain function. This review addresses the technical fundamentals, sonication parameters, experimental protocols, and monitoring techniques to examine the efficacy/safety in focused ultrasound-mediated blood-brain barrier disruption and discuss its potential translations to clinical use.

Original language	English
Pages (from-to)	104-117
Number of pages	14
Journal	Journal of Clinical Neurophysiology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1097/WNP.0000000000000488
Publication status	Published - 2020

Bibliographical note

Funding Information:
The authors have no conflicts of interest to disclose. This study was supported by the National Institutes of Health (RO1 MH111763) to A. Cammalleri, P. Croce, W. Lee, K. Yoon, and S-. S. Yoo. Address correspondence and reprint requests to Seung-Schik Yoo, PhD, MBA, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, U.S.A.; e-mail: yoo@bwh.harvard.edu. Copyright © 2020 by the American Clinical Neurophysiology Society ISSN: 0736-0258/20/3702-0104 DOI 10.1097/WNP.0000000000000488

Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.

All Science Journal Classification (ASJC) codes

Physiology
Neurology
Clinical Neurology
Physiology (medical)

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10.1097/WNP.0000000000000488

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abstract = "The demands for region-specific, noninvasive therapies for neurologic/psychiatric conditions are growing. The rise of transcranial focused ultrasound technology has witnessed temporary and reversible disruptions of the blood-brain barrier in the brain with exceptional control over the spatial precisions and depth, all in a noninvasive manner. Starting with small animal studies about a decade ago, the technique is now being explored in nonhuman primates and humans for the assessment of its efficacy and safety. The ability to transfer exogenous/endogenous therapeutic agents, cells, and biomolecules across the blood-brain barrier opens up new therapeutic avenues for various neurologic conditions, with a possibility to modulate the excitability of regional brain function. This review addresses the technical fundamentals, sonication parameters, experimental protocols, and monitoring techniques to examine the efficacy/safety in focused ultrasound-mediated blood-brain barrier disruption and discuss its potential translations to clinical use.",

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note = "Funding Information: The authors have no conflicts of interest to disclose. This study was supported by the National Institutes of Health (RO1 MH111763) to A. Cammalleri, P. Croce, W. Lee, K. Yoon, and S-. S. Yoo. Address correspondence and reprint requests to Seung-Schik Yoo, PhD, MBA, Department of Radiology, Brigham and Women{\textquoteright}s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, U.S.A.; e-mail: yoo@bwh.harvard.edu. Copyright {\textcopyright} 2020 by the American Clinical Neurophysiology Society ISSN: 0736-0258/20/3702-0104 DOI 10.1097/WNP.0000000000000488 Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved.",

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Therapeutic Potentials of Localized Blood-Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review

Abstract

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