Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum

Young Ki Lee, Hyun Jung Jun, Ji Hae Nahm, Tae Seop Lim, Ji Soo Park, Joong Bae Ahn, Sun Young Rha, Hyun Cheol Chung, Hwa Eun Oh, Ji Sun Song, Woo Ick Yang, Hyo Song Kim

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Abstract

Objective: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. Methods: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. Results: Of the 15 cases, 8 and 7 presented with single and multiple lesions, respectively. All cases with single lesions were asymptomatic, while 4 out of the 7 cases with multiple lesions were symptomatic. After tumor excision, none of the eight single-lesion cases experienced tumor recurrence. Among the other seven cases with multiple lesions, only one patient with disseminated lesions died due to disease burden. Five patients with multiple lesions received cisplatin- based intravenous or intraperitoneal chemotherapy, with a mix of complete (n = 2) and partial (n = 2) responses observed. Of particular note, one patient receiving cisplatin and pemetrexed combination chemotherapy experienced complete tumor resolution without any serious toxicity. Conclusions:We recommend different treatment strategies based on the disease status. If the tumor is completely resectable, an excisional biopsy seems to be sufficient. If complete resection is unavailable for the asymptomatic patient with a localized tumor extent, close follow-up is an appropriate option. When the tumor is extensive or accompanied by symptoms, chemotherapy should be strongly considered.

Original languageEnglish
Article numberhyt117
Pages (from-to)996-1003
Number of pages8
JournalJapanese Journal of Clinical Oncology
Volume43
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

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Peritoneum
Mesothelioma
Neoplasms
Cisplatin
Pemetrexed
Therapeutics
Drug Therapy
Rare Diseases
Combination Drug Therapy
Biopsy
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Lee, Y. K., Jun, H. J., Nahm, J. H., Lim, T. S., Park, J. S., Ahn, J. B., ... Kim, H. S. (2013). Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum. Japanese Journal of Clinical Oncology, 43(10), 996-1003. [hyt117]. https://doi.org/10.1093/jjco/hyt117
Lee, Young Ki ; Jun, Hyun Jung ; Nahm, Ji Hae ; Lim, Tae Seop ; Park, Ji Soo ; Ahn, Joong Bae ; Rha, Sun Young ; Chung, Hyun Cheol ; Oh, Hwa Eun ; Song, Ji Sun ; Yang, Woo Ick ; Kim, Hyo Song. / Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum. In: Japanese Journal of Clinical Oncology. 2013 ; Vol. 43, No. 10. pp. 996-1003.
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title = "Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum",
abstract = "Objective: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. Methods: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. Results: Of the 15 cases, 8 and 7 presented with single and multiple lesions, respectively. All cases with single lesions were asymptomatic, while 4 out of the 7 cases with multiple lesions were symptomatic. After tumor excision, none of the eight single-lesion cases experienced tumor recurrence. Among the other seven cases with multiple lesions, only one patient with disseminated lesions died due to disease burden. Five patients with multiple lesions received cisplatin- based intravenous or intraperitoneal chemotherapy, with a mix of complete (n = 2) and partial (n = 2) responses observed. Of particular note, one patient receiving cisplatin and pemetrexed combination chemotherapy experienced complete tumor resolution without any serious toxicity. Conclusions:We recommend different treatment strategies based on the disease status. If the tumor is completely resectable, an excisional biopsy seems to be sufficient. If complete resection is unavailable for the asymptomatic patient with a localized tumor extent, close follow-up is an appropriate option. When the tumor is extensive or accompanied by symptoms, chemotherapy should be strongly considered.",
author = "Lee, {Young Ki} and Jun, {Hyun Jung} and Nahm, {Ji Hae} and Lim, {Tae Seop} and Park, {Ji Soo} and Ahn, {Joong Bae} and Rha, {Sun Young} and Chung, {Hyun Cheol} and Oh, {Hwa Eun} and Song, {Ji Sun} and Yang, {Woo Ick} and Kim, {Hyo Song}",
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Lee, YK, Jun, HJ, Nahm, JH, Lim, TS, Park, JS, Ahn, JB, Rha, SY, Chung, HC, Oh, HE, Song, JS, Yang, WI & Kim, HS 2013, 'Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum', Japanese Journal of Clinical Oncology, vol. 43, no. 10, hyt117, pp. 996-1003. https://doi.org/10.1093/jjco/hyt117

Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum. / Lee, Young Ki; Jun, Hyun Jung; Nahm, Ji Hae; Lim, Tae Seop; Park, Ji Soo; Ahn, Joong Bae; Rha, Sun Young; Chung, Hyun Cheol; Oh, Hwa Eun; Song, Ji Sun; Yang, Woo Ick; Kim, Hyo Song.

In: Japanese Journal of Clinical Oncology, Vol. 43, No. 10, hyt117, 01.10.2013, p. 996-1003.

Research output: Contribution to journalArticle

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T1 - Therapeutic strategies forwell-differentiated papillary mesothelioma of the peritoneum

AU - Lee, Young Ki

AU - Jun, Hyun Jung

AU - Nahm, Ji Hae

AU - Lim, Tae Seop

AU - Park, Ji Soo

AU - Ahn, Joong Bae

AU - Rha, Sun Young

AU - Chung, Hyun Cheol

AU - Oh, Hwa Eun

AU - Song, Ji Sun

AU - Yang, Woo Ick

AU - Kim, Hyo Song

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Objective: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. Methods: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. Results: Of the 15 cases, 8 and 7 presented with single and multiple lesions, respectively. All cases with single lesions were asymptomatic, while 4 out of the 7 cases with multiple lesions were symptomatic. After tumor excision, none of the eight single-lesion cases experienced tumor recurrence. Among the other seven cases with multiple lesions, only one patient with disseminated lesions died due to disease burden. Five patients with multiple lesions received cisplatin- based intravenous or intraperitoneal chemotherapy, with a mix of complete (n = 2) and partial (n = 2) responses observed. Of particular note, one patient receiving cisplatin and pemetrexed combination chemotherapy experienced complete tumor resolution without any serious toxicity. Conclusions:We recommend different treatment strategies based on the disease status. If the tumor is completely resectable, an excisional biopsy seems to be sufficient. If complete resection is unavailable for the asymptomatic patient with a localized tumor extent, close follow-up is an appropriate option. When the tumor is extensive or accompanied by symptoms, chemotherapy should be strongly considered.

AB - Objective: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. Methods: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. Results: Of the 15 cases, 8 and 7 presented with single and multiple lesions, respectively. All cases with single lesions were asymptomatic, while 4 out of the 7 cases with multiple lesions were symptomatic. After tumor excision, none of the eight single-lesion cases experienced tumor recurrence. Among the other seven cases with multiple lesions, only one patient with disseminated lesions died due to disease burden. Five patients with multiple lesions received cisplatin- based intravenous or intraperitoneal chemotherapy, with a mix of complete (n = 2) and partial (n = 2) responses observed. Of particular note, one patient receiving cisplatin and pemetrexed combination chemotherapy experienced complete tumor resolution without any serious toxicity. Conclusions:We recommend different treatment strategies based on the disease status. If the tumor is completely resectable, an excisional biopsy seems to be sufficient. If complete resection is unavailable for the asymptomatic patient with a localized tumor extent, close follow-up is an appropriate option. When the tumor is extensive or accompanied by symptoms, chemotherapy should be strongly considered.

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