Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats

Joohyun Park, Jong Youl Kim, Seong Kyoon Choi, Jae Young Kim, Jae Hwan Kim, Won Bae Jeon, Jong Eun Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.

Original languageEnglish
Pages (from-to)1853-1862
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - 2017 Aug

Fingerprint

Elastin
Polypeptides
Cerebral Hemorrhage
Biocompatible Materials
Collagenases
Biomaterials
Hematoma
Rats
Peptides
Biopolymers
von Willebrand Factor
Microglia
Cytotoxicity
Microvessels
Immunoglobulin G
Mortality

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Park, Joohyun ; Kim, Jong Youl ; Choi, Seong Kyoon ; Kim, Jae Young ; Kim, Jae Hwan ; Jeon, Won Bae ; Lee, Jong Eun. / Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2017 ; Vol. 13, No. 6. pp. 1853-1862.
@article{03d3d3c1a0844eeb9e77ff683d5730f3,
title = "Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats",
abstract = "Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.",
author = "Joohyun Park and Kim, {Jong Youl} and Choi, {Seong Kyoon} and Kim, {Jae Young} and Kim, {Jae Hwan} and Jeon, {Won Bae} and Lee, {Jong Eun}",
year = "2017",
month = "8",
doi = "10.1016/j.nano.2017.04.001",
language = "English",
volume = "13",
pages = "1853--1862",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "6",

}

Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats. / Park, Joohyun; Kim, Jong Youl; Choi, Seong Kyoon; Kim, Jae Young; Kim, Jae Hwan; Jeon, Won Bae; Lee, Jong Eun.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 6, 08.2017, p. 1853-1862.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats

AU - Park, Joohyun

AU - Kim, Jong Youl

AU - Choi, Seong Kyoon

AU - Kim, Jae Young

AU - Kim, Jae Hwan

AU - Jeon, Won Bae

AU - Lee, Jong Eun

PY - 2017/8

Y1 - 2017/8

N2 - Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.

AB - Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.

UR - http://www.scopus.com/inward/record.url?scp=85020776494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020776494&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2017.04.001

DO - 10.1016/j.nano.2017.04.001

M3 - Article

C2 - 28412143

AN - SCOPUS:85020776494

VL - 13

SP - 1853

EP - 1862

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 6

ER -