Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

Sung Wook Choi; Hye Young Kwon; Woo Sik Kim; Jung Hyun Kim

doi:10.1016/S0927-7757(01)01042-1

Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

Sung Wook Choi, Hye Young Kwon, Woo Sik Kim, Jung Hyun Kim

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (D_sw, D_ws), exchange ratio (R = D_sw/D_ws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

Original language	English
Pages (from-to)	283-289
Number of pages	7
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	201
Issue number	1-3
DOIs	https://doi.org/10.1016/S0927-7757(01)01042-1
Publication status	Published - 2002 Mar 5

Bibliographical note

Funding Information:
The authors acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-N-NL-01-C-032).

All Science Journal Classification (ASJC) codes

Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/S0927-7757(01)01042-1

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title = "Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process",

abstract = "The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.",

author = "Choi, {Sung Wook} and Kwon, {Hye Young} and Kim, {Woo Sik} and Kim, {Jung Hyun}",

note = "Funding Information: The authors acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-N-NL-01-C-032). ",

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AU - Choi, Sung Wook

AU - Kwon, Hye Young

AU - Kim, Woo Sik

AU - Kim, Jung Hyun

N1 - Funding Information: The authors acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-N-NL-01-C-032).

PY - 2002/3/5

Y1 - 2002/3/5

N2 - The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

AB - The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

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Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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