The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.
|Number of pages||7|
|Journal||Colloids and Surfaces A: Physicochemical and Engineering Aspects|
|Publication status||Published - 2002 Mar 5|
Bibliographical noteFunding Information:
The authors acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-N-NL-01-C-032).
All Science Journal Classification (ASJC) codes
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry