Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

Sung Wook Choi, Hye Young Kwon, Woo Sik Kim, Jung Hyun Kim

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75 Citations (Scopus)


The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Issue number1-3
Publication statusPublished - 2002 Mar 5

Bibliographical note

Funding Information:
The authors acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-N-NL-01-C-032).

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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