Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

Sung Wook Choi, Hye Young Kwon, Woo Sik Kim, Jung-Hyun Kim

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume201
Issue number1-3
DOIs
Publication statusPublished - 2002 Mar 5

Fingerprint

Emulsification
Particle size
Thermodynamics
Nanoparticles
nanoparticles
thermodynamics
Polymers
polymers
globules
Supersaturation
supersaturation
Oils
diffusion coefficient
oils
polylactic acid-polyglycolic acid copolymer
interactions

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

@article{e4fbcf6420e74418a68da58bcfff20ce,
title = "Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process",
abstract = "The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.",
author = "Choi, {Sung Wook} and Kwon, {Hye Young} and Kim, {Woo Sik} and Jung-Hyun Kim",
year = "2002",
month = "3",
day = "5",
doi = "10.1016/S0927-7757(01)01042-1",
language = "English",
volume = "201",
pages = "283--289",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
issn = "0927-7757",
publisher = "Elsevier",
number = "1-3",

}

Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process. / Choi, Sung Wook; Kwon, Hye Young; Kim, Woo Sik; Kim, Jung-Hyun.

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 201, No. 1-3, 05.03.2002, p. 283-289.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Thermodynamic parameters on poly(D, L-lactide-co-glycolide) particle size in emulsification-diffusion process

AU - Choi, Sung Wook

AU - Kwon, Hye Young

AU - Kim, Woo Sik

AU - Kim, Jung-Hyun

PY - 2002/3/5

Y1 - 2002/3/5

N2 - The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

AB - The emulsification-diffusion method was thermodynamically studied for making poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles quantitatively considering the diffusion and the solvent-polymer interaction. The properties of various solvents and polymer were also evaluated on the formation of PLGA nanoparticles, such as diffusion coefficients (Dsw, Dws), exchange ratio (R = Dsw/Dws), and solvent-polymer interaction parameter (χ). R was found to be proportional to the size of the PLGA nanoparticles, while χ was inversely proportional to it. In the case of the higher value of R and lower value of χ, a small local supersaturation region was produced at the O/W interface and the small nanoparticles separated from the oil globule were formed in that region. This thermodynamic approach provides a rational basis for the selection of solvent to control the size of PLGA nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=0037022763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037022763&partnerID=8YFLogxK

U2 - 10.1016/S0927-7757(01)01042-1

DO - 10.1016/S0927-7757(01)01042-1

M3 - Article

VL - 201

SP - 283

EP - 289

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

SN - 0927-7757

IS - 1-3

ER -