Thermosensitive chitosans as novel injectable biomaterials

Ho Jin Chung, Jin Woo Bae, Hyung Dal Park, jinwoo lee, Ki Dong Park

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Two kinds of water soluble thermosensitive chitosan copolymers were prepared by graft polymerization of N-isopropylacrylamide (NIPAAm) onto chitosan using cerium ammonium nitrate (CAN) as an initiator (chitosan-g-NIPAAm) and by coupling monocarboxy Pluronic® with chitosan using 1-ethyl-3-(3- dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling agents (chitosan-Pluronic®). The physicochemical properties of the resulting copolymers were characterized and they formed thermally reversible hydrogel, which exhibits a lower critical solution temperature (LCST) at 34°C in aqueous solutions. The human mesenchymal stem cells (hMSCs) were cultured in the chiotsan-g-NIPAAm in vitro. Chondrogenic differentiation was induced in the chitosan-g-NIPAAm gel. Therefore, chondrogenic differentiated cells from MSCs with a thermosensitive chitosan-g-NIPAAm could be used as an injectable cell-polymer complex. In summary, chitosan-g-NIPAAm and chitosan-Pluronic® attest to their usefulness as injectable materials because of their thermally reversible property and relatively good biocompatibility.

Original languageEnglish
Pages (from-to)275-286
Number of pages12
JournalMacromolecular Symposia
Volume224
DOIs
Publication statusPublished - 2005 Apr 1

Fingerprint

Chitosan
Biocompatible Materials
Biomaterials
copolymers
ammonium nitrates
stem cells
biocompatibility
initiators
cerium
cells
Poloxamer
polymerization
gels
aqueous solutions
polymers
water
Copolymers
Ethyldimethylaminopropyl Carbodiimide
Cerium
temperature

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Chung, Ho Jin ; Bae, Jin Woo ; Park, Hyung Dal ; lee, jinwoo ; Park, Ki Dong. / Thermosensitive chitosans as novel injectable biomaterials. In: Macromolecular Symposia. 2005 ; Vol. 224. pp. 275-286.
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Thermosensitive chitosans as novel injectable biomaterials. / Chung, Ho Jin; Bae, Jin Woo; Park, Hyung Dal; lee, jinwoo; Park, Ki Dong.

In: Macromolecular Symposia, Vol. 224, 01.04.2005, p. 275-286.

Research output: Contribution to journalArticle

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