Thiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages

Rayun Choi, Jaemoon Yang, Jihye Choi, Eun Kyung Lim, Eunjung Kim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Thiolated dextran-coated gold nanorods (DEX-GNRs) were synthesized for targeted delivery to inflammatory macrophages and their photothermal ablation under near-infrared (NIR) light irradiation. Successful synthesis of DEX-GNRs was achieved using thiolated dextran, generated by applying mercaptopropionic acid to transform a hydroxyl group of dextran into a thiol group which has strong binding affinity with surfaces of GNRs. We confirmed both the existence of a thiol group in the functionalized dextran using Ellman's reagent in a thiol group assay and the characteristic band of DEX-GNRs using FT-IR spectrum. Furthermore, a cellular uptake study revealed that dextran showed a superior ability to bind the GNRs surface against macrophages compared to those of PEGylated GNRs with various molecular weights of polyethyleneglycol (PEG). Consequently, an in vitro phothothermal irradiation experiment using NIR light indicated that DEX-GNRs exhibited a significant cell-killing efficacy, even with a lower concentration of Au and a low-power light source.

Original languageEnglish
Pages (from-to)17520-17527
Number of pages8
JournalLangmuir
Volume26
Issue number22
DOIs
Publication statusPublished - 2010 Nov 16

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Fingerprint Dive into the research topics of 'Thiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages'. Together they form a unique fingerprint.

  • Cite this