Three different aspheric treatment algorithms of laser-assisted sub-epithelial keratectomy in patients with high myopia

Ji Min Ahn, Bong Joon Choi, Eung Kweon Kim, Bradford Sgrignoli, Tae Im Kim

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7 Citations (Scopus)


Purpose: To compare visual outcomes and quality in high myopia patients treated using one of three aspheric treatment algorithms based on the NIDEK Advanced Vision Excimer Laser System. Methods: Sixty eyes of 60 high myopia patients (>-6 diopter) underwent topography-guided (CATz) (20 eyes), wavefront-guided (OPDCAT) (20 eyes), or topography and wavefront-guided (OPA) (20 eyes) laser-assisted sub-epithelial keratectomy. Visual acuity, manifest refraction spherical equivalent (MRSE), ocular and corneal higher order aberrations, corneal asphericity, point spread function (Strehl ratio) and modulation transfer function (MTF) were compared preoperatively and 1, 3 and 6 months postoperatively. Results: Six months after surgery, logMAR uncorrected visual acuity was 0.02 ± 0.09 in the CATz group, 0.02 ± 0.07 in the OPDCAT group and 0.02 ± 0.08 in the OPA group, and there were no statistically significant differences (P = 0.5355). No statistical differences were found among the three groups in MRSE (P = 0.3541). Induced spherical aberrations and the change of corneal asphericity were less in the OPA group than in the others (P < 0.0001). The MTF was slightly better in the OPA group than in the others. The Strehl ratio showed no statistically significant differences among the three groups. Conclusions: All three aspheric treatment algorithms were safe and effective in correcting high myopia. Among them, the OPA algorithm maintained optical quality and physiologic cornea longer than the others.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalJapanese Journal of Ophthalmology
Issue number2
Publication statusPublished - 2013 Mar

Bibliographical note

Funding Information:
Acknowledgments We would like to acknowledge Yura Shin from Hankuk Academy of Foreign Studies for her help with analysis of the clinical data and the correction of English in the study. This study was supported by grant MEST (supported in part by grant MEST 2010-0022006) from the National Research Foundation of Korea and the Converging Research Center Program funded by the Ministry of Education, Science and Technology (2012K001354).

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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