Abstract
Background and purpose To explore the validity of the ESTRO-clinical target volume (CTV), we conducted three-dimensional analyses of locoregional recurrence (LRR) patterns according to the ESTRO- and RTOG-CTVs. Moreover, we explored which factors contribute to metastasis development outside the recommended CTV. Materials and methods We identified patients with post-treatment LRR explicitly exhibited on computed tomography (CT) images. All recurrences on CT were overlaid on representative CT images at the equivalent location, based on reference anatomic structures. Results A total of 235 recurrent lesions were identified in 129 patients. We depicted all LRR patterns in relation to the ESTRO- and RTOG-CTVs on CT and maximum intensity projection images. The ESTRO-CTV successfully contained the extent of the LRR within the RTOG-CTV in 96.4% of all early-stage breast-conserved women. Geographic misses of local recurrence were frequently observed in mastectomy patients (P = .002) and tended to originate from deep, but thin, chest walls. The rate of geographic misses of regional recurrence was low (3.6%) at the early stage, but increased in patients aged <45 years and with triple-negative tumors (P < .05). Conclusions Application of the ESTRO-CTV in early-stage disease seems justified.
| Original language | English |
|---|---|
| Pages (from-to) | 24-29 |
| Number of pages | 6 |
| Journal | Radiotherapy and Oncology |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging
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Three-dimensional analysis of patterns of locoregional recurrence after treatment in breast cancer patients : Validation of the ESTRO consensus guideline on target volume. / Chang, Jee Suk; Byun, Hwa Kyung; Kim, Jun Won; Kim, Kyung Hwan; Lee, Jeongshim; Cho, Yeona; Lee, Ik Jae; Keum, Ki Chang; Suh, Chang Ok; Kim, Yong Bae.
In: Radiotherapy and Oncology, Vol. 122, No. 1, 01.01.2017, p. 24-29.Research output: Contribution to journal › Article
TY - JOUR
T1 - Three-dimensional analysis of patterns of locoregional recurrence after treatment in breast cancer patients
T2 - Validation of the ESTRO consensus guideline on target volume
AU - Chang, Jee Suk
AU - Byun, Hwa Kyung
AU - Kim, Jun Won
AU - Kim, Kyung Hwan
AU - Lee, Jeongshim
AU - Cho, Yeona
AU - Lee, Ik Jae
AU - Keum, Ki Chang
AU - Suh, Chang Ok
AU - Kim, Yong Bae
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background and purpose To explore the validity of the ESTRO-clinical target volume (CTV), we conducted three-dimensional analyses of locoregional recurrence (LRR) patterns according to the ESTRO- and RTOG-CTVs. Moreover, we explored which factors contribute to metastasis development outside the recommended CTV. Materials and methods We identified patients with post-treatment LRR explicitly exhibited on computed tomography (CT) images. All recurrences on CT were overlaid on representative CT images at the equivalent location, based on reference anatomic structures. Results A total of 235 recurrent lesions were identified in 129 patients. We depicted all LRR patterns in relation to the ESTRO- and RTOG-CTVs on CT and maximum intensity projection images. The ESTRO-CTV successfully contained the extent of the LRR within the RTOG-CTV in 96.4% of all early-stage breast-conserved women. Geographic misses of local recurrence were frequently observed in mastectomy patients (P = .002) and tended to originate from deep, but thin, chest walls. The rate of geographic misses of regional recurrence was low (3.6%) at the early stage, but increased in patients aged <45 years and with triple-negative tumors (P < .05). Conclusions Application of the ESTRO-CTV in early-stage disease seems justified.
AB - Background and purpose To explore the validity of the ESTRO-clinical target volume (CTV), we conducted three-dimensional analyses of locoregional recurrence (LRR) patterns according to the ESTRO- and RTOG-CTVs. Moreover, we explored which factors contribute to metastasis development outside the recommended CTV. Materials and methods We identified patients with post-treatment LRR explicitly exhibited on computed tomography (CT) images. All recurrences on CT were overlaid on representative CT images at the equivalent location, based on reference anatomic structures. Results A total of 235 recurrent lesions were identified in 129 patients. We depicted all LRR patterns in relation to the ESTRO- and RTOG-CTVs on CT and maximum intensity projection images. The ESTRO-CTV successfully contained the extent of the LRR within the RTOG-CTV in 96.4% of all early-stage breast-conserved women. Geographic misses of local recurrence were frequently observed in mastectomy patients (P = .002) and tended to originate from deep, but thin, chest walls. The rate of geographic misses of regional recurrence was low (3.6%) at the early stage, but increased in patients aged <45 years and with triple-negative tumors (P < .05). Conclusions Application of the ESTRO-CTV in early-stage disease seems justified.
UR - http://www.scopus.com/inward/record.url?scp=85011103558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011103558&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2016.10.016
DO - 10.1016/j.radonc.2016.10.016
M3 - Article
C2 - 27838150
AN - SCOPUS:85011103558
VL - 122
SP - 24
EP - 29
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 1
ER -