Abstract
Background and purpose To explore the validity of the ESTRO-clinical target volume (CTV), we conducted three-dimensional analyses of locoregional recurrence (LRR) patterns according to the ESTRO- and RTOG-CTVs. Moreover, we explored which factors contribute to metastasis development outside the recommended CTV. Materials and methods We identified patients with post-treatment LRR explicitly exhibited on computed tomography (CT) images. All recurrences on CT were overlaid on representative CT images at the equivalent location, based on reference anatomic structures. Results A total of 235 recurrent lesions were identified in 129 patients. We depicted all LRR patterns in relation to the ESTRO- and RTOG-CTVs on CT and maximum intensity projection images. The ESTRO-CTV successfully contained the extent of the LRR within the RTOG-CTV in 96.4% of all early-stage breast-conserved women. Geographic misses of local recurrence were frequently observed in mastectomy patients (P = .002) and tended to originate from deep, but thin, chest walls. The rate of geographic misses of regional recurrence was low (3.6%) at the early stage, but increased in patients aged <45 years and with triple-negative tumors (P < .05). Conclusions Application of the ESTRO-CTV in early-stage disease seems justified.
Original language | English |
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Pages (from-to) | 24-29 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 122 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2017 Jan 1 |
Bibliographical note
Funding Information:This study was supported by a faculty research grant from Yonsei University College of Medicine for 2015 (6-2015-0038).
Publisher Copyright:
© 2016 Elsevier Ireland Ltd
All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging