Three-dimensional growth pattern of the rat mandible revealed by periodic live micro-computed tomography

Hak Jin Kim, Kyeong Mee Park, Hye Jin Tak, Ji Wook Choi, Sang Hoon Kang, Wonse Park, Sang Hwy Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective We wanted to evaluate the three-dimensional (3D) mandibular growth of Sprague-Dawley rats from 4th to 16th postnatal weeks with periodic and live micro-computed tomographic scanning. Design Twenty Sprague-Dawley rats were used for micro-CT scanning from 4th to 16th postnatal weeks. After 3D reconstruction of rat mandible, we performed the linear and angular measurements and the superimposition of the 3D models to evaluate the mandibular growth of rat. Results The results showed that the growth direction of the condylar and coronoid regions was superior primarily and posterior secondarily, while the condyle had minimal lateral growth. Moreover, the angular region was growing mainly toward the posterior and lateral direction, while the body and symphysis maintained small, incremental anterior-posterior growth. Conclusions We could evaluate the amount, rate, and direction of growth using the mandibular skeletal unit. Some reference points and measurements were more relevant in properly characterizing 3D growth of the mandible. Their growth rates were the greatest between 4th and 8th postnatal weeks, a period which seems most appropriate for studies of rat mandible growth.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalArchives of Oral Biology
Volume87
DOIs
Publication statusPublished - 2018 Mar

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2017R1A2B4005319 ) for S.-H. Lee.

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (2017R1A2B4005319) for S.-H. Lee.

Publisher Copyright:
© 2017 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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