Three-Dimensional Rapid Prototyping of Multidirectional Polymer Nanoprobes for Single Cell Insertion

Dasom Yang, Hyeonaug Hong, Yoon Ho Seo, Lo Hyun Kim, Won Hyoung Ryu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Three-dimensional (3D) thermal drawing at nanoscale as a novel rapid prototyping method was demonstrated to create multidirectional polymer nanoprobes for single cell analysis. This 3D drawing enables simple and rapid fabrication of polymeric nanostructures with high aspect ratio. The effect of thermal drawing parameters, such as drawing speeds, dipping depths, and contact duration on the final geometry of polymer nanostructures was investigated. Vertically aligned and L-shaped nanoprobes were fabricated and their insertion into living single cells such as algal cells and human neural stem cells was demonstrated. This technique can be extended to create more complex 3D structures by controlling drawing steps and directions on any surface.

Original languageEnglish
Pages (from-to)16873-16880
Number of pages8
JournalACS Applied Materials and Interfaces
Volume7
Issue number30
DOIs
Publication statusPublished - 2015 Aug 5

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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