Three new flavonol glycosides from Fissistigma pallens

Nguyen Xuan Nhiem, Ngo Sy Thinh, Nguyen Thi Bich Thu, Luu The Anh, Tran Minh Ngoc, Bui Huu Tai, Pham Hai Yen, Phan van Kiem, Chau van Minh, Seonju Park, Seung Hyun Kim

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Three new flavonol glycosides, fissflavosides A-C (1–3), together with six known flavonol glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (4), kaempferol 3-O-α-L-rham-nopyranosyl-(1→6)-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (6), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (7), rutin (8), and isorhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (9) were isolated from the methanol extract of the Fissistigma pallens leaves. Their chemical structures were determined by 1D-, 2D-NMR, and MS data as well as in comparison with reported data in the literature. Compounds 1–9 showed weak cytotoxic activity on three human cancer cell lines, HT-29, A-2058, A-549 with IC50 ranging from 134.6 to 162.6 µM. In addition, the antioxidant capacities of compounds were also tested by ORAC assay. All compounds showed significant antioxidant with trolox equivalents ranging from 4.4 to 8.6 µM at the concentration of 1.0 µM. The results indicated 7 and 8 having meaningful reducing capacity of copper (I) ions of 2.7 to 6.9 µM at the concentrations of 1 and 2 µM.

Original languageEnglish
Pages (from-to)2177-2182
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Issue number12
Publication statusPublished - 2019 Jan 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Nhiem, N. X., Thinh, N. S., Thu, N. T. B., Anh, L. T., Ngoc, T. M., Tai, B. H., Yen, P. H., van Kiem, P., van Minh, C., Park, S., & Kim, S. H. (2019). Three new flavonol glycosides from Fissistigma pallens. Bioscience, Biotechnology and Biochemistry, 83(12), 2177-2182.