Three-port operation in three-zone simulated moving bed chromatography

Kyung Min Kim, Ji Yeon Song, Chang-Ha Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new operating method, namely three-port operation in a three-zone simulated moving bed (TT-SMB), was developed to improve the separation performance of simulated moving bed (SMB) chromatography. In the TT-SMB, the switching period consists of two steps; extract outlet port is closed at the first step for raffinate production and raffinate outlet port is closed at the second step for extract production. As a result, three ports were used in each step of the three-zone SMB operation. The separation performance of TT-SMB was compared with conventional three- and four-zone SMBs in terms of purity, recovery, productivity, and eluent consumption. A conventional three-zone SMB operation usually produced the contaminated portion at the product outlet node during the switching period. However, such phenomenon could be prevented by using the TT-SMB operation because one product outlet port was closed at each step. Compared to the conventional three-zone SMB, all performance parameters improved with the use of TT-SMB, and the improvement in purity and recovery was significant (up to 7%). Adjusting the step ratio played a key role in the trade-off between the performance parameters. The purity, recovery, and productivity of TT-SMB at well-designed step ratio conditions are up to 3% higher than those of the conventional four-zone methods (1-1-1-1 configuration).

Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalJournal of Chromatography A
Volume1340
DOIs
Publication statusPublished - 2014 May 2

Fingerprint

Chromatography
Recovery
Productivity

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

@article{74163eb5fa3c4586b3ea47f0729de440,
title = "Three-port operation in three-zone simulated moving bed chromatography",
abstract = "A new operating method, namely three-port operation in a three-zone simulated moving bed (TT-SMB), was developed to improve the separation performance of simulated moving bed (SMB) chromatography. In the TT-SMB, the switching period consists of two steps; extract outlet port is closed at the first step for raffinate production and raffinate outlet port is closed at the second step for extract production. As a result, three ports were used in each step of the three-zone SMB operation. The separation performance of TT-SMB was compared with conventional three- and four-zone SMBs in terms of purity, recovery, productivity, and eluent consumption. A conventional three-zone SMB operation usually produced the contaminated portion at the product outlet node during the switching period. However, such phenomenon could be prevented by using the TT-SMB operation because one product outlet port was closed at each step. Compared to the conventional three-zone SMB, all performance parameters improved with the use of TT-SMB, and the improvement in purity and recovery was significant (up to 7{\%}). Adjusting the step ratio played a key role in the trade-off between the performance parameters. The purity, recovery, and productivity of TT-SMB at well-designed step ratio conditions are up to 3{\%} higher than those of the conventional four-zone methods (1-1-1-1 configuration).",
author = "Kim, {Kyung Min} and Song, {Ji Yeon} and Chang-Ha Lee",
year = "2014",
month = "5",
day = "2",
doi = "10.1016/j.chroma.2014.03.012",
language = "English",
volume = "1340",
pages = "79--89",
journal = "Journal of Chromatography",
issn = "0021-9673",
publisher = "Elsevier",

}

Three-port operation in three-zone simulated moving bed chromatography. / Kim, Kyung Min; Song, Ji Yeon; Lee, Chang-Ha.

In: Journal of Chromatography A, Vol. 1340, 02.05.2014, p. 79-89.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Three-port operation in three-zone simulated moving bed chromatography

AU - Kim, Kyung Min

AU - Song, Ji Yeon

AU - Lee, Chang-Ha

PY - 2014/5/2

Y1 - 2014/5/2

N2 - A new operating method, namely three-port operation in a three-zone simulated moving bed (TT-SMB), was developed to improve the separation performance of simulated moving bed (SMB) chromatography. In the TT-SMB, the switching period consists of two steps; extract outlet port is closed at the first step for raffinate production and raffinate outlet port is closed at the second step for extract production. As a result, three ports were used in each step of the three-zone SMB operation. The separation performance of TT-SMB was compared with conventional three- and four-zone SMBs in terms of purity, recovery, productivity, and eluent consumption. A conventional three-zone SMB operation usually produced the contaminated portion at the product outlet node during the switching period. However, such phenomenon could be prevented by using the TT-SMB operation because one product outlet port was closed at each step. Compared to the conventional three-zone SMB, all performance parameters improved with the use of TT-SMB, and the improvement in purity and recovery was significant (up to 7%). Adjusting the step ratio played a key role in the trade-off between the performance parameters. The purity, recovery, and productivity of TT-SMB at well-designed step ratio conditions are up to 3% higher than those of the conventional four-zone methods (1-1-1-1 configuration).

AB - A new operating method, namely three-port operation in a three-zone simulated moving bed (TT-SMB), was developed to improve the separation performance of simulated moving bed (SMB) chromatography. In the TT-SMB, the switching period consists of two steps; extract outlet port is closed at the first step for raffinate production and raffinate outlet port is closed at the second step for extract production. As a result, three ports were used in each step of the three-zone SMB operation. The separation performance of TT-SMB was compared with conventional three- and four-zone SMBs in terms of purity, recovery, productivity, and eluent consumption. A conventional three-zone SMB operation usually produced the contaminated portion at the product outlet node during the switching period. However, such phenomenon could be prevented by using the TT-SMB operation because one product outlet port was closed at each step. Compared to the conventional three-zone SMB, all performance parameters improved with the use of TT-SMB, and the improvement in purity and recovery was significant (up to 7%). Adjusting the step ratio played a key role in the trade-off between the performance parameters. The purity, recovery, and productivity of TT-SMB at well-designed step ratio conditions are up to 3% higher than those of the conventional four-zone methods (1-1-1-1 configuration).

UR - http://www.scopus.com/inward/record.url?scp=84897961513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897961513&partnerID=8YFLogxK

U2 - 10.1016/j.chroma.2014.03.012

DO - 10.1016/j.chroma.2014.03.012

M3 - Article

C2 - 24661870

AN - SCOPUS:84897961513

VL - 1340

SP - 79

EP - 89

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

ER -