Three-step thermal drawing for rapid prototyping of highly customizable microneedles for vascular tissue insertion

Kangju Lee, Seung Hyun Park, Jiyong Lee, Suho Ryu, Chulmin Joo, Wonhyoung Ryu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.

Original languageEnglish
Article number100
JournalPharmaceutics
Volume11
Issue number3
DOIs
Publication statusPublished - 2019 Mar

Bibliographical note

Funding Information:
Funding: This research was supported by a grant of Korea Health Technology R & D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C1237), and by Mid-Career Researcher Program through NRF grant funded by the MEST (2016R1A2B4010487).

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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