Three-step thermal drawing for rapid prototyping of highly customizable microneedles for vascular tissue insertion

Kangju Lee, Seung Hyun Park, Jiyong Lee, Suho Ryu, Chulmin Joo, WonHyoung Ryu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.

Original languageEnglish
Article number100
JournalPharmaceutics
Volume11
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Blood Vessels
Hot Temperature
Temperature
Pharmaceutical Preparations
Anatomy
Polymers
Skin
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{7990be36846647cfa54e68a8b0f0ce24,
title = "Three-step thermal drawing for rapid prototyping of highly customizable microneedles for vascular tissue insertion",
abstract = "Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.",
author = "Kangju Lee and Park, {Seung Hyun} and Jiyong Lee and Suho Ryu and Chulmin Joo and WonHyoung Ryu",
year = "2019",
month = "3",
day = "1",
doi = "10.3390/pharmaceutics11030100",
language = "English",
volume = "11",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

Three-step thermal drawing for rapid prototyping of highly customizable microneedles for vascular tissue insertion. / Lee, Kangju; Park, Seung Hyun; Lee, Jiyong; Ryu, Suho; Joo, Chulmin; Ryu, WonHyoung.

In: Pharmaceutics, Vol. 11, No. 3, 100, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Three-step thermal drawing for rapid prototyping of highly customizable microneedles for vascular tissue insertion

AU - Lee, Kangju

AU - Park, Seung Hyun

AU - Lee, Jiyong

AU - Ryu, Suho

AU - Joo, Chulmin

AU - Ryu, WonHyoung

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.

AB - Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.

UR - http://www.scopus.com/inward/record.url?scp=85063369222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063369222&partnerID=8YFLogxK

U2 - 10.3390/pharmaceutics11030100

DO - 10.3390/pharmaceutics11030100

M3 - Article

VL - 11

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 3

M1 - 100

ER -