Three-year follow-up of laser in situ keratomileusis treatments for myopia: Multi-center cohort study in korean population

Jae Yong Kim, Hun Lee, Choun Ki Joo, Joon Young Hyon, Tae Im Kim, Jin Hyoung Kim, Jin Kuk Kim, Eun Young Cho, Ji Eun Choi, Na Rae Lee, Hung Won Tchah

Research output: Contribution to journalArticlepeer-review

Abstract

This multi-center cohort study included 3401 myopic laser in situ keratomileusis (LASIK) procedures conducted in 1756 myopia patients between 2002 and 2005. Pre-and postoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and manifest refraction spherical equivalent (SE) were recorded. Factors predicting low postoperative efficacy (defined as a postoperative UCVA < 0.5) were identified using univariate and multivariate logistic regression analysis. Compared with 1 month postoperatively, logMAR UCVA at 3 months postoperatively was significantly decreased (p = 0.002) and that at 2 and 3 years was significantly increased (p < 0.001). LogMAR BCVA at 2 years postoperatively was significantly decreased compared with 1 month postoperatively (p = 0.008). Over the 3-year postoperative period, overall refractive predictability within ±1.00 D and ±0.50 D ranged from 69.0% to 86.2% and from 43.3% to 67.8%, respectively. This also decreased from 1 month to 6 months postoperatively (p < 0.005). Multivariate logistic regression analysis using generalized estimating equations, revealed that higher preoperative SE (odds ratio [OR], 2.58 and 7.23; p < 0.001) and lower preoperative BCVA (OR, 2.44; p = 0.003) were predictive of a low postoperative efficacy. In summary, myopic LASIK can be effective and safe with a high refractive predictability in a Korean population, but myopic regression occurs over time. Higher preoperative SE and lower preoperative BCVA are predictive of a low postoperative efficacy.

Original languageEnglish
Article number419
JournalJournal of Personalized Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
Funding: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2020R1F1A1073627), by a grant (NRF-2018R1D1A1B0704) from the National Research Foundation of Korea, and by a grant (2019IP0464) from the Asan Institute for Life Sciences, Seoul, Republic of Korea.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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