Thyroid incidentalomas detected on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography: Thyroid Imaging Reporting and Data System (TIRADS) in the diagnosis and management of patients

Jung Hyun Yoon, Arthur Cho, Hye Sun Lee, Eun Kyung Kim, Hee Jung Moon, Jin Young Kwak

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10 Citations (Scopus)

Abstract

Background Our aim was to evaluate the role of the Thyroid Imaging Reporting and Data System (TIRADS) in the risk stratification of thyroid incidentalomas detected on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) scans. Methods Eighty-seven thyroid nodules in 84 patients showing incidentally detected increased uptake on 18F-FDG-PET/CT who also had ultrasonography (US)-guided fine needle aspiration performed were included. On review of the US images, a TIRADS category was assigned to each thyroid nodule based on the number of suspicious US features. The correlation between the TIRADS category and the standard uptake values (SUV) on 18F-FDG-PET/CT were calculated and compared. Results Of the 87 thyroid nodules, 47 (54%) were benign, and 40 (46%) were malignant. The malignancy rate of the TIRADS categories were as follows: 9% for category 3, 15% for category 4a, 39% for category 4b, 72% for category 4c, and 100.0% for category 5. Combining the TIRADS with the SUV showed increased specificity and positive predictive value but decreased sensitivity and negative predictive value compared with TIRADS alone (all P < .05). The area under the receiver operating characteristics curve value of TIRADS was the greatest, comparable with the combined TIRADS and SUV (0.737 to 0.724, P = .788). Conclusion TIRADS may be applied in the risk stratification of thyroid incidentalomas detected on 18F-FDG-PET/CT. Considering the high malignancy rate of thyroid incidentalomas showing increased 18F-FDG uptake, ultrasonography-guided fine needle aspiration is mandatory even if there are no suspicious features present on US.

Original languageEnglish
Article number4105
Pages (from-to)1314-1322
Number of pages9
JournalSurgery (United States)
Volume158
Issue number5
DOIs
Publication statusPublished - 2015 Nov

All Science Journal Classification (ASJC) codes

  • Surgery

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