Thyroid incidentalomas identified by18F-FDG PET: Sonographic correlation

Young Kwak Jin, Eun Kyung Kim, Mijin Yun, Arthur Cho, Jung Kim Min, Ju Son Eun, Keun Oh Ki

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE. The purpose of this study was to evaluate the risk of malignancy of thyroid incidentalomas detected on 18F-FDG PET and the diagnostic accuracy of sonography for differentiating benign from malignant focal thyroid incidentalomas that were detected on FDG PET. MATERIALS AND METHODS. Retrospective review was performed of a database of 87 focal thyroid lesions seen on FDG PET and sonography. Forty-two focal lesions were malignant. We compared the accuracy of the maximum standard uptake value (SUV) to differentiate benign from malignant thyroid lesions. We classified the thyroid nodules as probably benign or suspicious for malignancy by the sonographic features. Statistical analyses compared two subgroups by sonographic classifications between benign and malignant thyroid lesions. RESULTS. The maximum SUV of the malignant nodules was not significantly higher than that of benign lesions. Thirty-seven (75.5%) of 49 lesions with suspicious sonographic findings revealed malignancy on cytopathology, compared with five (13.2%) of 38 lesions that showed probably benign sonographic findings. These differences were statistically significant using a kappa test (κ = 0.675, p = 0.001) and logistic regression (odds ratio = 26.2, p = 0.001). CONCLUSION. The probability (48.3%) of malignancy of focal thyroid incidentalomas seen on FDG PET is high. The maximum SUV of thyroid cancer is not significantly higher than that of benign lesions. The probability (13.2%) of malignancy is much lower when the sonographic findings appear benign, as compared with a significantly higher probability (75.5%) of malignancy when the sonographic findings are suspicious for malignancy.

Original languageEnglish
Pages (from-to)598-603
Number of pages6
JournalAmerican Journal of Roentgenology
Volume191
Issue number2
DOIs
Publication statusPublished - 2008 Aug 15

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Thyroid Gland
Neoplasms
Ultrasonography
Thyroid Nodule
Pets
Fluorodeoxyglucose F18
Thyroid Neoplasms
Logistic Models
Odds Ratio
Databases

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Jin, Young Kwak ; Kim, Eun Kyung ; Yun, Mijin ; Cho, Arthur ; Min, Jung Kim ; Eun, Ju Son ; Ki, Keun Oh. / Thyroid incidentalomas identified by18F-FDG PET : Sonographic correlation. In: American Journal of Roentgenology. 2008 ; Vol. 191, No. 2. pp. 598-603.
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abstract = "OBJECTIVE. The purpose of this study was to evaluate the risk of malignancy of thyroid incidentalomas detected on 18F-FDG PET and the diagnostic accuracy of sonography for differentiating benign from malignant focal thyroid incidentalomas that were detected on FDG PET. MATERIALS AND METHODS. Retrospective review was performed of a database of 87 focal thyroid lesions seen on FDG PET and sonography. Forty-two focal lesions were malignant. We compared the accuracy of the maximum standard uptake value (SUV) to differentiate benign from malignant thyroid lesions. We classified the thyroid nodules as probably benign or suspicious for malignancy by the sonographic features. Statistical analyses compared two subgroups by sonographic classifications between benign and malignant thyroid lesions. RESULTS. The maximum SUV of the malignant nodules was not significantly higher than that of benign lesions. Thirty-seven (75.5{\%}) of 49 lesions with suspicious sonographic findings revealed malignancy on cytopathology, compared with five (13.2{\%}) of 38 lesions that showed probably benign sonographic findings. These differences were statistically significant using a kappa test (κ = 0.675, p = 0.001) and logistic regression (odds ratio = 26.2, p = 0.001). CONCLUSION. The probability (48.3{\%}) of malignancy of focal thyroid incidentalomas seen on FDG PET is high. The maximum SUV of thyroid cancer is not significantly higher than that of benign lesions. The probability (13.2{\%}) of malignancy is much lower when the sonographic findings appear benign, as compared with a significantly higher probability (75.5{\%}) of malignancy when the sonographic findings are suspicious for malignancy.",
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Thyroid incidentalomas identified by18F-FDG PET : Sonographic correlation. / Jin, Young Kwak; Kim, Eun Kyung; Yun, Mijin; Cho, Arthur; Min, Jung Kim; Eun, Ju Son; Ki, Keun Oh.

In: American Journal of Roentgenology, Vol. 191, No. 2, 15.08.2008, p. 598-603.

Research output: Contribution to journalArticle

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T1 - Thyroid incidentalomas identified by18F-FDG PET

T2 - Sonographic correlation

AU - Jin, Young Kwak

AU - Kim, Eun Kyung

AU - Yun, Mijin

AU - Cho, Arthur

AU - Min, Jung Kim

AU - Eun, Ju Son

AU - Ki, Keun Oh

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N2 - OBJECTIVE. The purpose of this study was to evaluate the risk of malignancy of thyroid incidentalomas detected on 18F-FDG PET and the diagnostic accuracy of sonography for differentiating benign from malignant focal thyroid incidentalomas that were detected on FDG PET. MATERIALS AND METHODS. Retrospective review was performed of a database of 87 focal thyroid lesions seen on FDG PET and sonography. Forty-two focal lesions were malignant. We compared the accuracy of the maximum standard uptake value (SUV) to differentiate benign from malignant thyroid lesions. We classified the thyroid nodules as probably benign or suspicious for malignancy by the sonographic features. Statistical analyses compared two subgroups by sonographic classifications between benign and malignant thyroid lesions. RESULTS. The maximum SUV of the malignant nodules was not significantly higher than that of benign lesions. Thirty-seven (75.5%) of 49 lesions with suspicious sonographic findings revealed malignancy on cytopathology, compared with five (13.2%) of 38 lesions that showed probably benign sonographic findings. These differences were statistically significant using a kappa test (κ = 0.675, p = 0.001) and logistic regression (odds ratio = 26.2, p = 0.001). CONCLUSION. The probability (48.3%) of malignancy of focal thyroid incidentalomas seen on FDG PET is high. The maximum SUV of thyroid cancer is not significantly higher than that of benign lesions. The probability (13.2%) of malignancy is much lower when the sonographic findings appear benign, as compared with a significantly higher probability (75.5%) of malignancy when the sonographic findings are suspicious for malignancy.

AB - OBJECTIVE. The purpose of this study was to evaluate the risk of malignancy of thyroid incidentalomas detected on 18F-FDG PET and the diagnostic accuracy of sonography for differentiating benign from malignant focal thyroid incidentalomas that were detected on FDG PET. MATERIALS AND METHODS. Retrospective review was performed of a database of 87 focal thyroid lesions seen on FDG PET and sonography. Forty-two focal lesions were malignant. We compared the accuracy of the maximum standard uptake value (SUV) to differentiate benign from malignant thyroid lesions. We classified the thyroid nodules as probably benign or suspicious for malignancy by the sonographic features. Statistical analyses compared two subgroups by sonographic classifications between benign and malignant thyroid lesions. RESULTS. The maximum SUV of the malignant nodules was not significantly higher than that of benign lesions. Thirty-seven (75.5%) of 49 lesions with suspicious sonographic findings revealed malignancy on cytopathology, compared with five (13.2%) of 38 lesions that showed probably benign sonographic findings. These differences were statistically significant using a kappa test (κ = 0.675, p = 0.001) and logistic regression (odds ratio = 26.2, p = 0.001). CONCLUSION. The probability (48.3%) of malignancy of focal thyroid incidentalomas seen on FDG PET is high. The maximum SUV of thyroid cancer is not significantly higher than that of benign lesions. The probability (13.2%) of malignancy is much lower when the sonographic findings appear benign, as compared with a significantly higher probability (75.5%) of malignancy when the sonographic findings are suspicious for malignancy.

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