Thyroid nodules with nondiagnostic results on repeat fine-needle aspiration biopsy

Which nodules should be considered for repeat biopsy or surgery rather than follow-up?

Na Lae Eun, Mi Ri Yoo, Hye Mi Gweon, Ah Young Park, Jeong Ah Kim, Ji Hyun Youk, Hee Jung Moon, Hang-Seok Chang, Eun Ju Son

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The goal of this study was to assess the clinicopathologic and ultrasonographic features of thyroid nodules with nondiagnostic results on repeat ultrasonography (US)-guided fineneedle aspiration biopsy (FNAB) according to size and the number of suspicious findings and to determine the proper management of nodules with consecutive nondiagnostic results. Methods: This retrospective study included 297 nodules with nondiagnostic results on repeat FNAB that were evaluated by US over the course of at least 12 months of follow-up, a follow-up biopsy, or an operation. We compared clinical and US variables between benign and malignant nodules in thyroid nodules with repeat nondiagnostic results. Results: The comparison of benign and malignant nodules with repeat nondiagnostic results revealed that age, marked hypoechogenicity, irregular or microlobulated margins, microcalcifications, and nonparallel shape were significantly associated with malignancy. Multivariate logistic regression analysis in malignant nodules revealed that microcalcifications and irregular or microlobulated margins were independently associated with malignancy. Among them, only irregular or microlobulated margins were independently significant as a predictor of malignancy in repeatedly nondiagnostic nodules measuring >10 mm. Using receiver operating characteristic analysis, the best cutoff value for the “number of suspicious findings” between benign and malignant nodules was three in nodules of all sizes, three in nodules measuring ≤10 mm, and two in nodules measuring >10 mm. Conclusion: Irregular or microlobulated margins may be the most frequent US features in repeatedly nondiagnostic nodules >10 mm. The presence of “two or more suspicious findings” can be used as the cutoff for distinguishing benign and malignant nodules.

Original languageEnglish
Pages (from-to)234-243
Number of pages10
JournalUltrasonography
Volume35
Issue number3
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Thyroid Nodule
Fine Needle Biopsy
Ultrasonography
Biopsy
Calcinosis
Needle Biopsy
Neoplasms
ROC Curve
Retrospective Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Eun, Na Lae ; Yoo, Mi Ri ; Gweon, Hye Mi ; Park, Ah Young ; Kim, Jeong Ah ; Youk, Ji Hyun ; Moon, Hee Jung ; Chang, Hang-Seok ; Son, Eun Ju. / Thyroid nodules with nondiagnostic results on repeat fine-needle aspiration biopsy : Which nodules should be considered for repeat biopsy or surgery rather than follow-up?. In: Ultrasonography. 2016 ; Vol. 35, No. 3. pp. 234-243.
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abstract = "Purpose: The goal of this study was to assess the clinicopathologic and ultrasonographic features of thyroid nodules with nondiagnostic results on repeat ultrasonography (US)-guided fineneedle aspiration biopsy (FNAB) according to size and the number of suspicious findings and to determine the proper management of nodules with consecutive nondiagnostic results. Methods: This retrospective study included 297 nodules with nondiagnostic results on repeat FNAB that were evaluated by US over the course of at least 12 months of follow-up, a follow-up biopsy, or an operation. We compared clinical and US variables between benign and malignant nodules in thyroid nodules with repeat nondiagnostic results. Results: The comparison of benign and malignant nodules with repeat nondiagnostic results revealed that age, marked hypoechogenicity, irregular or microlobulated margins, microcalcifications, and nonparallel shape were significantly associated with malignancy. Multivariate logistic regression analysis in malignant nodules revealed that microcalcifications and irregular or microlobulated margins were independently associated with malignancy. Among them, only irregular or microlobulated margins were independently significant as a predictor of malignancy in repeatedly nondiagnostic nodules measuring >10 mm. Using receiver operating characteristic analysis, the best cutoff value for the “number of suspicious findings” between benign and malignant nodules was three in nodules of all sizes, three in nodules measuring ≤10 mm, and two in nodules measuring >10 mm. Conclusion: Irregular or microlobulated margins may be the most frequent US features in repeatedly nondiagnostic nodules >10 mm. The presence of “two or more suspicious findings” can be used as the cutoff for distinguishing benign and malignant nodules.",
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Thyroid nodules with nondiagnostic results on repeat fine-needle aspiration biopsy : Which nodules should be considered for repeat biopsy or surgery rather than follow-up? / Eun, Na Lae; Yoo, Mi Ri; Gweon, Hye Mi; Park, Ah Young; Kim, Jeong Ah; Youk, Ji Hyun; Moon, Hee Jung; Chang, Hang-Seok; Son, Eun Ju.

In: Ultrasonography, Vol. 35, No. 3, 01.07.2016, p. 234-243.

Research output: Contribution to journalArticle

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AU - Eun, Na Lae

AU - Yoo, Mi Ri

AU - Gweon, Hye Mi

AU - Park, Ah Young

AU - Kim, Jeong Ah

AU - Youk, Ji Hyun

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AU - Chang, Hang-Seok

AU - Son, Eun Ju

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