Time-Domain Optimal Experimental Design in Human Seated Postural Control Testing

M. Cody Priess, Jongeun Choi, Clark Radcliffe, John M. Popovich, Jacek Cholewicki, N. Peter Reeves

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We are developing a series of systems science-based clinical tools that will assist in modeling, diagnosing, and quantifying postural control deficits in human subjects. In line with this goal, we have designed and constructed a seated balance device and associated experimental task for identification of the human seated postural control system. In this work, we present a quadratic programming (QP) technique for optimizing a time-domain experimental input signal for this device. The goal of this optimization is to maximize the information present in the experiment, and therefore its ability to produce accurate estimates of several desired seated postural control parameters. To achieve this, we formulate the problem as a nonconvex QP and attempt to locally maximize a measure (T-optimality condition) of the experiment's Fisher information matrix (FIM) under several constraints. These constraints include limits on the input amplitude, physiological output magnitude, subject control amplitude, and input signal autocorrelation. Because the autocorrelation constraint takes the form of a quadratic constraint (QC), we replace it with a conservative linear relaxation about a nominal point, which is iteratively updated during the course of optimization. We show that this iterative descent algorithm generates a convergent suboptimal solution that guarantees monotonic nonincreasing of the cost function value while satisfying all constraints during iterations. Finally, we present successful experimental results using an optimized input sequence.

Original languageEnglish
Article number054501
JournalJournal of Dynamic Systems, Measurement and Control, Transactions of the ASME
Issue number5
Publication statusPublished - 2015 May 1

Bibliographical note

Publisher Copyright:
© 2015 by ASME.

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Information Systems
  • Instrumentation
  • Mechanical Engineering
  • Computer Science Applications


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