Abstract
Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.
| Original language | English |
|---|---|
| Pages (from-to) | 3428-3433 |
| Number of pages | 6 |
| Journal | Chest |
| Volume | 128 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine
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Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy. / Ha, Jong Won; Cho, Jung Rae; Kim, Jin Mi; Ahn, Jeong Ah; Choi, Eui Young; kang, seokmin; Rim, Se Joong; Chung, Namsik.
In: Chest, Vol. 128, No. 5, 01.01.2005, p. 3428-3433.Research output: Contribution to journal › Article
TY - JOUR
T1 - Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy
AU - Ha, Jong Won
AU - Cho, Jung Rae
AU - Kim, Jin Mi
AU - Ahn, Jeong Ah
AU - Choi, Eui Young
AU - kang, seokmin
AU - Rim, Se Joong
AU - Chung, Namsik
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.
AB - Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.
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U2 - 10.1378/chest.128.5.3428
DO - 10.1378/chest.128.5.3428
M3 - Article
VL - 128
SP - 3428
EP - 3433
JO - Chest
JF - Chest
SN - 0012-3692
IS - 5
ER -