Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy

Jong Won Ha, Jung Rae Cho, Jin Mi Kim, Jeong Ah Ahn, Eui Young Choi, seokmin kang, Se Joong Rim, Namsik Chung

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.

Original languageEnglish
Pages (from-to)3428-3433
Number of pages6
JournalChest
Volume128
Issue number5
DOIs
Publication statusPublished - 2005 Jan 1

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Hypertrophic Cardiomyopathy
Exercise
Brain Natriuretic Peptide
Deceleration
Ventricular Pressure
Left Ventricular Function
Immunoassay
Echocardiography
Multivariate Analysis
Gases
Oxygen

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ha, Jong Won ; Cho, Jung Rae ; Kim, Jin Mi ; Ahn, Jeong Ah ; Choi, Eui Young ; kang, seokmin ; Rim, Se Joong ; Chung, Namsik. / Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy. In: Chest. 2005 ; Vol. 128, No. 5. pp. 3428-3433.
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abstract = "Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.",
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Ha, JW, Cho, JR, Kim, JM, Ahn, JA, Choi, EY, kang, S, Rim, SJ & Chung, N 2005, 'Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy', Chest, vol. 128, no. 5, pp. 3428-3433. https://doi.org/10.1378/chest.128.5.3428

Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy. / Ha, Jong Won; Cho, Jung Rae; Kim, Jin Mi; Ahn, Jeong Ah; Choi, Eui Young; kang, seokmin; Rim, Se Joong; Chung, Namsik.

In: Chest, Vol. 128, No. 5, 01.01.2005, p. 3428-3433.

Research output: Contribution to journalArticle

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T1 - Tissue doppler-derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy

AU - Ha, Jong Won

AU - Cho, Jung Rae

AU - Kim, Jin Mi

AU - Ahn, Jeong Ah

AU - Choi, Eui Young

AU - kang, seokmin

AU - Rim, Se Joong

AU - Chung, Namsik

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.

AB - Background: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. Patients: Twenty-nine patients with ApHCM (24 men; mean age ± SD, 57 ± 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. Results: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (V̇O2max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and V̇O2max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and V̇O2max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of V̇O2max by multivariate analysis (p = 0.0106). Conclusions: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.

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